Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT13EW)

• Drug Name: AMINOBENZTROPINE Drug Info
• Synonyms: Aminobenztropine; CHEMBL330957; 88097-86-3; 3-(2'-Aminobenzhydryloxy)tropane; ABHT; Aminobenztropine, solid; Spectrum_000273; SpecPlus_000797; Spectrum5_001758; Spectrum4_001211; Spectrum3_000745; AC1L1D0L; AC1Q57ZN; Lopac0_000126; KBioGR_001642; BSPBio_002330; KBioSS_000753; MLS000859976; SPECTRUM2300334; DivK1c_006893; SCHEMBL1231000; 2-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy-phenylmethyl]aniline; KBio3_001550; KBio2_003321; KBio1_001837; KBio2_005889; KBio2_000753; CTK5F9344; CHEBI:125384; HMS3260I14; HMS3374M03; HMS2232P19
• Cross-matching ID:
  PubChem CID: 2143
  ChEBI ID: CHEMBL125384
  CAS Number: CAS 88097-86-3
  TTD Drug ID: D03WGD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Allograft rejection	1.84	4.16e-2	32/38 (84.21%)	GZMB;PRF1;HLA-DPA1;...
Base excision repair	1.84	3.12e-2	29/33 (87.88%)	POLE2;POLD3;POLB;...
Autoimmune thyroid disease	1.83	2.60e-2	46/53 (86.79%)	GZMB;PRF1;HLA-DPA1;...
Tyrosine metabolism	-1.72	3.83e-2	30/36 (83.33%)	TYR;MIF;ADH5;...
Drug metabolism	-1.77	1.78e-2	78/151 (51.66%)	RRM2;ALDH3B1;NME4;...
Bile secretion	-1.79	1.75e-2	68/90 (75.56%)	CA2;BAAT;SLC5A1;...
Steroid hormone biosynthesis	-1.89	7.66e-3	43/61 (70.49%)	HSD3B1;CYP19A1;CYP2E1;...
Bacterial invasion of epithelial cells	-1.96	2.39e-3	59/77 (76.62%)	ITGB1;CTNNB1;ARPC3;...
Complement and coagulation cascades	-2.18	0.00e+0	76/85 (89.41%)	F9;SERPIND1;VWF;...
Metabolism of xenobiotics by cytochrome P450	-2.22	0.00e+0	49/77 (63.64%)	ALDH3B1;GSTA3;MGST3;...
Retinol metabolism	-2.42	0.00e+0	41/68 (60.29%)	CYP1A1;RDH16;UGT2B15;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲