General Information of Drug (ID: DMT1I52)

Drug Name
Cycloserine Drug Info
Synonyms
D-cycloserine; cycloserine; 68-41-7; Seromycin; orientomycin; Oxamycin; Cyclorin; Cyclo-D-serine; Wasserina; Farmiserina; Tisomycin; Cicloserina; Miroseryn; Closina; D-4-amino-3-isoxazolidinone; (R)-4-AMINOISOXAZOLIDIN-3-ONE; alpha-Cycloserine; (+)-4-Amino-3-isoxazolidinone; Miroserina; Cycloserinum; D-4-amino-3-isoxazolidone; Oxamicina; (4R)-4-aminoisoxazolidin-3-one; PA 94; (+)-Cycloserine; (4R)-4-amino-1,2-oxazolidin-3-one; Oxamicina [Italian]; Cycloserin; Micoserina; Cicloserina [Italian]; PA-94; Tebemicina; Novoserin; D-Oxamycin; Cicloserina; Closerin; Orientomycin; C 3909; Alpha-Cycloserine; C-9390; C-9400; Cicloserina [INN-Spanish]; Cycloserinum [INN-Latin]; D-CS; DRG-0195; I-1431; K-300; SC-49088; Seromycin (TN); Cycloserine [INN:BAN:JAN]; E-733-A; RO-1-9213; Cycloserine (JP15/USP/INN); D-amino-3-isoxazolidinone; D-(+)-Cycloserine; D-4-Amino-3-isossazolidone; D-4-Amino-3-isossazolidone [Italian]; FA6C7F8B-D080-4EA3-978F-1ECFB5A29D09; R-(+)-Cycloserine; R-4-Amino-3-isoxazolidinone; R(+)-4-Amino-3-isoxazolidinone; (4R)-4-Amino-3-isoxazolidinone; (R)-(+)-4-Amino-3-isoxazolidinone; (R)-(+)-Cycloserine; (R)-4-AMINO-ISOXAZOLIDIN-3-ONE; (R)-4-Amino-3-isoxazolidinone; (R)-4-Amino-3-isoxazolidone; (R)-Cycloserine; 3-Isoxazolidinone, 4-amino-, (+)-(8CI); 3-Isoxazolidinone, 4-amino-, (4R)-(9CI); 3-Isoxazolidinone, 4-amino-, (R); 3-Isoxazolidinone, 4-amino-, D; (R)-4-Amino-Isoxazolidin-3-One
Therapeutic ClassAntiinfective Agents
Cross-matching ID
PubChem CID
6234
ChEBI ID
CHEMBL771
CAS Number
CAS 68-41-7
TTD Drug ID
D02WFK
VARIDT Drug ID
DR00197
ACDINA Drug ID
D00158

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Morphine addiction 1.63 4.26e-1 80/91 (87.91%) GNG11;PDE10A;GABRP;...
Mucin type O-glycan biosynthesis 1.59 4.17e-1 20/36 (55.56%) GALNT7;GALNT14;GALNT12;...
Fructose and mannose metabolism 1.53 5.07e-1 30/33 (90.91%) AKR1B1;HK2;SORD;...
Neomycin, kanamycin and gentamicin biosynthesis 1.46 5.13e-1 5/5 (100%) HK2;HK3
Longevity regulating pathway 1.43 5.12e-1 90/151 (59.6%) SOD2;INSR;ATG101;...
Non-small cell lung cancer 1.43 4.77e-1 70/72 (97.22%) E2F2;MET;PRKCB;...
Inositol phosphate metabolism 1.42 4.55e-1 66/73 (90.41%) IMPA1;PLCB4;CDIPT;...
Primary immunodeficiency 1.42 4.36e-1 33/38 (86.84%) IL7R;CD40;CD19;...
Phosphatidylinositol signaling system 1.41 4.24e-1 82/97 (84.54%) PRKCB;DGKD;PRKCA;...
Tryptophan metabolism 1.41 3.97e-1 35/42 (83.33%) ALDH2;KYNU;CYP1B1;...
Carbohydrate digestion and absorption 1.39 4.15e-1 37/47 (78.72%) PRKCB;HK2;PLCB4;...
Insulin resistance 1.38 4.20e-1 96/108 (88.89%) GFPT2;INSR;PRKCB;...
Chemokine signaling pathway 1.37 4.38e-1 163/192 (84.9%) GNG11;PF4;LYN;...
Autophagy 1.37 4.13e-1 113/169 (66.86%) RRAGD;ATG101;EIF2AK3;...
Regulation of lipolysis in adipocytes 1.36 4.25e-1 52/55 (94.55%) PLAAT3;INSR;IRS2;...
Galactose metabolism 1.35 4.19e-1 26/31 (83.87%) AKR1B1;HK2;MGAM;...
Autoimmune thyroid disease 1.34 4.43e-1 46/53 (86.79%) HLA-DMB;CD40;GZMB;...
Spinocerebellar ataxia 1.33 4.65e-1 128/143 (89.51%) PSMB7;PRKCB;ATG101;...
Ovarian steroidogenesis 1.32 4.69e-1 41/51 (80.39%) INSR;ALOX5;HSD17B2;...
Glycerophospholipid metabolism 1.31 4.67e-1 71/98 (72.45%) PLAAT3;CHPT1;DGKD;...
Transcriptional misregulation in cancer 1.31 4.60e-1 158/192 (82.29%) PAX5;BCL11B;MET;...
Mannose type O-glycan biosynthesis 1.31 4.50e-1 14/23 (60.87%) RXYLT1;POMT1;B4GAT1;...
GABAergic synapse 1.29 4.76e-1 76/89 (85.39%) GNG11;GABRP;PRKCB;...
Cell adhesion molecules 1.29 4.71e-1 118/148 (79.73%) PTPRM;NFASC;NRCAM;...
Protein processing in endoplasmic reticulum 1.27 5.34e-1 127/171 (74.27%) GANAB;RAD23B;DNAJC1;...
GnRH secretion 1.22 5.35e-1 60/64 (93.75%) GNA11;PRKCB;PRKCA;...
Other glycan degradation 1.22 5.37e-1 13/18 (72.22%) FUCA1;HEXB;MANBA;...
Glycerolipid metabolism 1.22 5.27e-1 44/61 (72.13%) ALDH2;DGKD;AKR1B1;...
Aminoacyl-tRNA biosynthesis 1.14 5.37e-1 15/66 (22.73%) QRSL1;NARS2;FARSA;...
RNA transport 1.14 5.31e-1 128/186 (68.82%) EIF5;EIF2S3;PNN;...
Peroxisome -1.32 3.90e-1 72/82 (87.8%) XDH;SOD1;GSTK1;...
cGMP-PKG signaling pathway -1.32 3.84e-1 145/167 (86.83%) PPP1CB;MYLK;PLCB1;...
Bile secretion -1.33 3.86e-1 68/90 (75.56%) UGT2B17;ADCY8;SLC10A2;...
Prostate cancer -1.34 3.78e-1 93/97 (95.88%) HSP90AB1;PIK3CA;TCF7L2;...
Staphylococcus aureus infection -1.35 3.59e-1 72/95 (75.79%) C1QB;DEFA4;DEFA5;...
Cardiac muscle contraction -1.36 3.68e-1 64/87 (73.56%) CACNB3;CACNB2;ATP2A1;...
Synthesis and degradation of ketone bodies -1.36 3.74e-1 9/10 (90%) HMGCL;HMGCS2;BDH2;...
Necroptosis -1.36 3.86e-1 113/159 (71.07%) NLRP3;TRADD;IFNA16;...
Fatty acid degradation -1.37 3.76e-1 40/43 (93.02%) ADH1C;ACOX1;ACADM;...
Rap1 signaling pathway -1.38 3.79e-1 184/210 (87.62%) ADORA2B;SIPA1L3;PDGFD;...
TGF-beta signaling pathway -1.38 3.76e-1 81/94 (86.17%) TFDP1;TGFBR2;PPP2CB;...
Fat digestion and absorption -1.39 3.82e-1 35/43 (81.4%) PLA2G10;MOGAT2;AGPAT1;...
Renin secretion -1.42 3.30e-1 61/69 (88.41%) EDN1;AQP1;NPR1;...
Pertussis -1.42 3.37e-1 64/76 (84.21%) JUN;MAPK13;CASP7;...
Vascular smooth muscle contraction -1.44 3.08e-1 113/133 (84.96%) PLA2G10;KCNMB2;KCNMA1;...
Renin-angiotensin system -1.44 3.19e-1 20/23 (86.96%) CPA3;PREP;CTSG;...
Adrenergic signaling in cardiomyocytes -1.49 2.41e-1 130/150 (86.67%) TNNI3;MAPK13;TNNT2;...
Caffeine metabolism -1.49 2.48e-1 5/6 (83.33%) NAT2;NAT1
RIG-I-like receptor signaling pathway -1.50 2.63e-1 64/70 (91.43%) MAVS;IFNA6;MAPK8;...
Butanoate metabolism -1.51 2.54e-1 23/28 (82.14%) ACSM5;ALDH5A1;HMGCL;...
ECM-receptor interaction -1.52 2.60e-1 80/88 (90.91%) ITGB6;ITGB4;HMMR;...
Focal adhesion -1.53 2.77e-1 180/201 (89.55%) IBSP;RHOA;ITGA5;...
D-Glutamine and D-glutamate metabolism -1.53 2.79e-1 5/5 (100%) GLUD1;GLUD2
PPAR signaling pathway -1.55 2.75e-1 66/74 (89.19%) CD36;SLC27A2;CYP7A1;...
Arrhythmogenic right ventricular cardiomyopathy -1.56 2.91e-1 70/77 (90.91%) ITGA9;ITGA5;CACNB3;...
Vasopressin-regulated water reabsorption -1.59 2.49e-1 40/44 (90.91%) DCTN6;DYNLL1;ARHGDIA;...
Steroid hormone biosynthesis -1.60 2.82e-1 43/61 (70.49%) CYP7A1;DHRS11;AKR1C4;...
Proximal tubule bicarbonate reclamation -1.62 2.85e-1 21/23 (91.3%) CA4;ATP1B2;ATP1A2;...
Hypertrophic cardiomyopathy -1.63 3.61e-1 81/90 (90%) ITGA5;CACNB3;CACNB2;...
Mineral absorption -1.82 9.58e-2 48/60 (80%) S100G;VDR;HMOX1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H