Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT2EJP)

Drug Name
Podofilox Drug Info
Synonyms
podophyllotoxin; 518-28-5; Condylox; Condyline; Wartec; Podophyllotoxin 7; Podophyllinic acid lactone; Warticon; (-)-Podophyllotoxin; Podofilox [USAN]; CCRIS 565; UNII-L36H50F353; Podophyllotoxin, 95%; HSDB 7238; NSC24818; CHEMBL61; EINECS 208-250-4; NSC 24818; (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; MLS000069495; AI3-50456; CHEBI:50305; Podofilox (USAN); L36H50F353; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,; Podophyllotoxin
Cross-matching ID
PubChem CID
10607
ChEBI ID
CHEMBL61
CAS Number
CAS 518-28-5
TTD Drug ID
D0D4HN
INTEDE Drug ID
DR1310
ACDINA Drug ID
D01348

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
HIF-1 signaling pathway 2.02 0.00e+0 105/109 (96.33%) HMOX1;HK2;VEGFA;...
Basal cell carcinoma 1.91 6.48e-3 41/63 (65.08%) CDKN1A;WNT5A;BMP2;...
Morphine addiction 1.86 4.32e-3 80/91 (87.91%) PDE8B;PDE10A;GNG12;...
Mineral absorption 1.86 3.24e-3 48/60 (80%) HMOX1;MT2A;MT1H;...
GnRH secretion 1.78 1.81e-2 60/64 (93.75%) KCNN4;GNA11;PRKCB;...
Melanogenesis 1.78 2.16e-2 74/101 (73.27%) MITF;PRKCB;ADCY2;...
Neomycin, kanamycin and gentamicin biosynthesis 1.77 2.04e-2 5/5 (100%) HK2;HK3;HK1
Insulin secretion 1.75 2.10e-2 75/86 (87.21%) KCNN4;GNA11;PRKCB;...
Thyroid hormone synthesis 1.73 2.73e-2 66/75 (88%) ALB;HSPA5;GPX1;...
Cholinergic synapse 1.72 2.72e-2 99/113 (87.61%) GNA11;GNG12;PRKCB;...
Hippo signaling pathway 1.72 2.47e-2 120/186 (64.52%) PRKCI;ID1;AREG;...
Growth hormone synthesis, secretion and action 1.71 2.37e-2 108/119 (90.76%) GNA11;STAT5B;PRKCB;...
Signaling pathways regulating pluripotency of stem cell... 1.71 2.59e-2 110/143 (76.92%) ID1;MEIS1;KLF4;...
Shigellosis 1.70 2.50e-2 180/246 (73.17%) HK2;ACTN1;CXCL8;...
Hepatocellular carcinoma 1.68 3.45e-2 135/168 (80.36%) HMOX1;CDKN1A;PRKCB;...
GABAergic synapse 1.67 3.48e-2 76/89 (85.39%) GNG12;PRKCB;ADCY2;...
Renal cell carcinoma 1.67 3.50e-2 68/69 (98.55%) VEGFA;CDKN1A;JUN;...
Estrogen signaling pathway 1.65 3.81e-2 119/137 (86.86%) KRT18;KRT13;KRT23;...
Gastric acid secretion 1.65 3.68e-2 63/76 (82.89%) EZR;PRKCB;ADCY2;...
ErbB signaling pathway 1.65 3.56e-2 79/85 (92.94%) CDKN1A;EREG;JUN;...
Leukocyte transendothelial migration 1.63 5.00e-2 90/114 (78.95%) ICAM1;EZR;ACTN1;...
Bacterial invasion of epithelial cells 1.62 4.84e-2 59/77 (76.62%) ITGA5;CDH1;PIK3CB;...
Viral protein interaction with cytokine and cytokine re... -1.74 3.84e-2 84/100 (84%) CCR7;CCL16;ACKR3;...
Graft-versus-host disease -1.76 4.13e-2 32/42 (76.19%) FASLG;PRF1;HLA-DPB1;...
Steroid hormone biosynthesis -1.77 4.41e-2 43/61 (70.49%) CYP11B2;HSD3B2;SULT1E1;...
Arachidonic acid metabolism -1.85 2.98e-2 48/61 (78.69%) PLA2G3;PLA2G2A;CYP2C9;...
Folate biosynthesis -1.99 1.32e-2 23/26 (88.46%) CBR1;DHFR;QDPR;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 3.33uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H
Urinary bladder
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H