Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT3KB4)

Drug Name
Lobeline Drug Info
Synonyms
lobeline; Lobelin; Inflatine; Lobeline [INN]; Lobelinum [INN-Latin]; Lobelina [INN-Spanish]; EINECS 202-012-3; BRN 0091533; AC1LEL62; ZINC56446; Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, (2R-(2alpha,6alpha(S*)))-; LS-88107
Cross-matching ID
PubChem CID
101616
ChEBI ID
CHEMBL122270
CAS Number
CAS 90-69-7
TTD Drug ID
D01IVE
VARIDT Drug ID
DR01063

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 1.96 1.18e-2 48/60 (80%) MT1E;MT1F;MT1X;...
Fanconi anemia pathway 1.85 3.25e-2 36/54 (66.67%) RPA3;USP1;PALB2;...
Homologous recombination 1.82 2.36e-2 35/41 (85.37%) RPA3;BARD1;MRE11;...
Steroid hormone biosynthesis -1.87 3.57e-2 43/61 (70.49%) CYP2E1;CYP3A7;AKR1C4;...
Bacterial invasion of epithelial cells -1.97 6.69e-3 59/77 (76.62%) PIK3R2;ITGB1;RAC1;...
Porphyrin and chlorophyll metabolism -2.08 0.00e+0 23/43 (53.49%) HCCS;ALAS2;UGT2B17;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H