Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT3ML6)

Drug Name
AG-213 Drug Info
Cross-matching ID
PubChem CID
667601
ChEBI ID
CHEMBL77030
CAS Number
CAS 122520-86-9
TTD Drug ID
D0Q3GG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nitrogen metabolism 1.98 1.05e-2 16/17 (94.12%) GLUL;CPS1;CA12;...
Retinol metabolism 1.95 1.05e-2 41/68 (60.29%) DHRS9;CYP26B1;ALDH1A2;...
Nicotine addiction 1.91 7.02e-3 32/40 (80%) GABRP;GRIA2;SLC17A7;...
Metabolism of xenobiotics by cytochrome P450 1.83 3.16e-2 49/77 (63.64%) ALDH3A1;HSD11B1;AKR1C1;...
Pyruvate metabolism 1.78 4.42e-2 41/47 (87.23%) GRHPR;ADH5;ADH1C;...
IL-17 signaling pathway 1.78 3.68e-2 84/94 (89.36%) MUC5B;S100A8;S100A9;...
Protein digestion and absorption -1.99 0.00e+0 78/103 (75.73%) MEP1B;CTRB2;CTRL;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H