Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT43AI)

• Drug Name: SIB-1508Y Drug Info
• Synonyms: CHEMBL111580; 3-ethynyl-5-(1-methylpyrrolidin-2-yl)pyridine; 179120-51-5; 5-Ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine; 5-Ethynyl Nicotine; 179120-92-4; 3-ethynyl-5-(1-methyl-2-pyrrolidinyl)pyridine; AC1L326X; SCHEMBL1155706; BDBM86544; NUPUDYKEEJNZRG-UHFFFAOYSA-N; CHEBI:125396; NSC_6442277; CAS_192231-16-6; 3-ethynyl-5-(1-methylpyrrolidin-2-yl)-pyridine; 3-(1-Methylpyrrolidine-2-yl)-5-ethynylpyridine; A812432
• Cross-matching ID:
  PubChem CID: 3036156
  ChEBI ID: CHEMBL111659
  CAS Number: CAS 179120-92-4
  TTD Drug ID: D0Y9HH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Retinol metabolism	1.92	3.93e-2	41/68 (60.29%)	ALDH1A1;UGT2B4;CYP2C9;...
Pentose and glucuronate interconversions	1.85	3.14e-2	17/34 (50%)	AKR1B10;AKR1A1;UGT2B4;...
Drug metabolism	1.79	4.72e-2	78/151 (51.66%)	UGT2B4;CYP2C9;UCK2;...
Steroid biosynthesis	-2.09	0.00e+0	19/20 (95%)	LSS;SC5D;SOAT2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲