Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT57WC)

Drug Name
Tetrahydrozoline Drug Info
Synonyms Tyzine
Cross-matching ID
PubChem CID
5419
ChEBI ID
CHEMBL28674
CAS Number
CAS 84-22-0
TTD Drug ID
D05IHU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.86 3.93e-2 110/124 (88.71%) CCNB1;CDC45;CDKN2C;...
Fat digestion and absorption 1.85 2.46e-2 35/43 (81.4%) PLA2G2A;ACAT2;FABP1;...
Systemic lupus erythematosus 1.79 3.93e-2 45/135 (33.33%) C1QA;C1QB;C1R;...
Steroid biosynthesis -1.82 2.80e-2 19/20 (95%) TM7SF2;CYP51A1;CYP24A1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.84 3.73e-2 62/70 (88.57%) MAPK13;MAP2K4;IKBKB;...
Protein processing in endoplasmic reticulum -2.05 5.08e-3 127/171 (74.27%) MAP3K5;HSPA1L;SEC23B;...
Collecting duct acid secretion -2.07 1.02e-2 22/27 (81.48%) ATP4A;TCIRG1;ATP6V1F;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H