Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMT68RG)

• Drug Name: K252a Drug Info
• Synonyms: K-252a, Nocardiopsis sp.; k-252a; ST50826373; (+)-K-252A; k-252a deriva-tives; AC1LAL9C; GTPL336; BDBM2580; CHEMBL416056; SCHEMBL13485248; HMS3229K08; ZINC3776578; 99533-80-9; CCG-206861; methyl hydroxy-methyl-oxo-[ ]carboxylate; B6828; methyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-16-carboxylate; methyl (16S,18S,15R)-1
• Cross-matching ID:
  PubChem CID: 3035817
  ChEBI ID: CHEMBL281948
  CAS Number: CAS 99533-80-9
  TTD Drug ID: D03DYT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
p53 signaling pathway	1.96	0.00e+0	63/73 (86.3%)	CCNG2;CDKN1A;DDB2;...
Amoebiasis	-1.68	4.84e-2	99/102 (97.06%)	LAMC3;PLCB1;CD1C;...
Pertussis	-1.71	3.30e-2	64/76 (84.21%)	JUN;NOS2;IRAK1;...
Mismatch repair	-1.71	3.51e-2	22/23 (95.65%)	RPA1;POLD1;RFC3;...
GnRH signaling pathway	-1.71	3.90e-2	80/93 (86.02%)	PRKACA;HBEGF;CALML4;...
Cysteine and methionine metabolism	-1.74	3.63e-2	43/50 (86%)	GOT2;BCAT2;MTAP;...
Dopaminergic synapse	-1.74	3.97e-2	115/132 (87.12%)	CAMK2A;DRD5;ATF6B;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.78	3.02e-2	62/70 (88.57%)	ATP6V1F;TJP1;MAPK9;...
Protein processing in endoplasmic reticulum	-1.82	2.42e-2	127/171 (74.27%)	MBTPS2;SEC62;PPP1R15A;...
Glycine, serine and threonine metabolism	-1.83	2.42e-2	31/40 (77.5%)	SRR;DLD;PGAM1;...
Proteasome	-2.06	0.00e+0	44/46 (95.65%)	PSMB2;PSMD3;PSMB7;...
IL-17 signaling pathway	-2.08	0.00e+0	84/94 (89.36%)	MMP3;DEFB4A;TRAF2;...
DNA replication	-2.30	0.00e+0	34/36 (94.44%)	MCM2;RFC3;RFC4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.37uM - 10uM	24H	Hide ▲

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.37uM - 10uM	24H	Hide ▲