Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTAFY4)

• Drug Name: Oxacillin Drug Info
• Synonyms: Bactocill; Ossacillina; Oxacilina; Oxacilline; Oxacillinum; Oxazocillin; Oxazocilline; Prostaphlin; Prostaphlyn; OXACILLIN SODIUM; Ossacillina [DCIT]; Sodium oxacillin; Bactocill (TN); MPI-penicillin; MPi-PC; Oxacilina (TN); Oxacilina [INN-Spanish]; Oxacillin (INN); Oxacillin [INN:BAN]; Oxacilline [INN-French]; Oxacillinum [INN-Latin]; Penicillin, Methylphenylisoxazolyl; Oxacillin, Monosodium Salt, Anhydrous; (2S,5R,6R)-3,3-dimethyl-6-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-dimethyl-6-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (5-methyl-3-phenyl-4-isoxazolyl)penicillin; 2,2-dimethyl-6beta-(5-methyl-3-phenyl-1,2-oxazole-4-carboxamido)penam-3alpha-carboxylic acid; 5-Methyl-3-phenyl-4-isoxazolyl-penicillin; 6beta-(5-methyl-3-phenylisoxazol-4-yl)penicillanic acid
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 6196
  ChEBI ID: CHEMBL819
  CAS Number: CAS 66-79-5
  TTD Drug ID: D0MB8I
  VARIDT Drug ID: DR00647
  INTEDE Drug ID: DR2321
  ACDINA Drug ID: D01306

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
RNA polymerase	2.10	0.00e+0	23/31 (74.19%)	POLR2I;POLR3G;POLR3K;...
Spliceosome	2.06	0.00e+0	101/150 (67.33%)	FUS;HSPA1A;CDC40;...
RNA transport	1.86	1.26e-2	128/186 (68.82%)	EIF5;FUS;NUP85;...
Ribosome	1.80	1.76e-2	113/158 (71.52%)	RPL36AL;RPS26;RPL10;...
Collecting duct acid secretion	-1.90	6.62e-3	22/27 (81.48%)	ATP6V1B1;ATP6V0A4;SLC12A7;...
PPAR signaling pathway	-1.93	8.82e-3	66/74 (89.19%)	ACSL1;ME1;ACSL3;...
Proximal tubule bicarbonate reclamation	-1.98	6.62e-3	21/23 (91.3%)	ATP1B3;SLC4A4;GLUD2;...
Protein digestion and absorption	-2.13	0.00e+0	78/103 (75.73%)	PRCP;MEP1A;SLC7A9;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	8uM	72H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼