Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTAJQE)

• Drug Name: Amphotericin B Drug Info
• Synonyms: ABLC; Abelcet; Abelecet; Ambisome; Amphocin; Amphomoronal; Amphotec; Amphotericin; Amphotericinum; Amphotherizin; Amphozone; Fungilin; Fungisome; Fungisone; Fungizone; Halizon; SinuNase; Amfotericina B; Amophotericin B; Amphortericin B; Amphotericin B Cholesterol Dispersion; Amphotericin B Colloidal Dispersion; Amphotericin B liposomal; Amphotericin BETA; Amphotericine B; Amphotericinum B; Amphotherizin [German]; Liposomal Amphotericin B; NCI527017; NS 718; AMPH-B; Abelcet (TN); AmBisome (TN); Amfotericina B [INN-Spanish]; Ampho-Moronal; Amphocil (TN); Amphotec (TN); Amphotericin-B; Amphotericine B [INN-French]; Amphotericinum B [INN-Latin]; Fungilin (TN); Fungisome (TN); Fungizone (TN); LNS-AmB; Mysteclin-F; NKTR-024; Amphotericin B [USAN:INN:JAN]; Amphotericin B, Lipid-based; Amphotericin B, Streptomyces sp.; Amphotericin B (JP15/USP/INN)
• Therapeutic Class: Antifungal Agents
• Cross-matching ID:
  PubChem CID: 5280965
  ChEBI ID: CHEMBL267345
  CAS Number: CAS 1397-89-3
  TTD Drug ID: D02DWM
  VARIDT Drug ID: DR01468

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Sphingolipid metabolism	2.09	0.00e+0	32/49 (65.31%)	UGCG;DEGS1;PLPP2;...
Steroid biosynthesis	2.03	0.00e+0	19/20 (95%)	SC5D;SQLE;MSMO1;...
Lysosome	1.95	2.78e-3	115/128 (89.84%)	NPC2;CTSH;FUCA1;...
NF-kappa B signaling pathway	-1.68	4.06e-2	90/104 (86.54%)	BTK;VCAM1;IL1B;...
One carbon pool by folate	-1.68	4.09e-2	15/20 (75%)	DHFR;SHMT2;MTHFD2;...
Amoebiasis	-1.68	4.25e-2	99/102 (97.06%)	PIK3R3;IL1B;CD1A;...
Mismatch repair	-1.69	3.69e-2	22/23 (95.65%)	RPA1;EXO1;POLD1;...
Citrate cycle (TCA cycle)	-1.71	3.48e-2	30/30 (100%)	SUCLA2;IDH3B;IDH2;...
Rheumatoid arthritis	-1.72	3.56e-2	78/93 (83.87%)	IL15;IL1B;IFNG;...
Nucleotide excision repair	-1.73	3.48e-2	40/47 (85.11%)	RFC3;XPA;GTF2H1;...
Viral protein interaction with cytokine and cytokine re...	-1.73	3.75e-2	84/100 (84%)	CCL17;PPBP;IL2RB;...
Systemic lupus erythematosus	-1.73	3.77e-2	45/135 (33.33%)	TRIM21;SNRPD3;TNF;...
Legionellosis	-1.74	3.90e-2	51/57 (89.47%)	HSPA8;HSPA1L;HSPD1;...
Retinol metabolism	-1.76	3.13e-2	41/68 (60.29%)	RETSAT;DHRS9;UGT2B4;...
Measles	-1.76	3.48e-2	133/139 (95.68%)	CCNE2;CCND2;EIF3H;...
Fanconi anemia pathway	-1.83	1.31e-2	36/54 (66.67%)	BRIP1;RPA1;BRCA2;...
IL-17 signaling pathway	-1.83	1.49e-2	84/94 (89.36%)	MAP3K7;ELAVL1;CCL17;...
TNF signaling pathway	-1.87	9.67e-3	103/112 (91.96%)	DNM1L;BAG4;CXCL5;...
Primary immunodeficiency	-1.88	9.28e-3	33/38 (86.84%)	LCK;CD19;BLNK;...
RNA transport	-1.88	1.16e-2	128/186 (68.82%)	RANGAP1;EIF4A2;ELAC1;...
Ribosome biogenesis in eukaryotes	-1.97	3.87e-3	52/108 (48.15%)	RPP40;SNU13;NMD3;...
DNA replication	-2.16	0.00e+0	34/36 (94.44%)	MCM6;RPA1;POLD1;...
Spliceosome	-2.41	0.00e+0	101/150 (67.33%)	CRNKL1;HNRNPA3;SRSF4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲