Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTAREC)

Drug Name
Rimexolone Drug Info
Synonyms Rimexolone (sustained release intra-articular steroid suspension, Plexis, arthritis)
Cross-matching ID
PubChem CID
5311412
ChEBI ID
CHEMBL1200617
CAS Number
CAS 49697-38-3
TTD Drug ID
D0D2TN
INTEDE Drug ID
DR1426
ACDINA Drug ID
D01394

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.10 0.00e+0 34/36 (94.44%) MCM2;PCNA;MCM6;...
Citrate cycle (TCA cycle) 2.08 0.00e+0 30/30 (100%) DLAT;PCK2;IDH2;...
Complement and coagulation cascades 2.04 3.29e-3 76/85 (89.41%) C3;F3;F13A1;...
Ribosome 1.97 2.47e-3 113/158 (71.52%) MRPS16;RPS5;MRPL15;...
Tyrosine metabolism 1.96 3.95e-3 30/36 (83.33%) MAOA;AOX1;ADH1B;...
Oxidative phosphorylation 1.92 8.24e-3 93/133 (69.92%) ATP5MC3;NDUFS4;NDUFB5;...
PPAR signaling pathway 1.89 9.88e-3 66/74 (89.19%) LPL;PLIN2;CPT1A;...
Non-alcoholic fatty liver disease 1.88 8.65e-3 126/155 (81.29%) IRS2;PRKAG2;PPARG;...
Glyoxylate and dicarboxylate metabolism 1.85 1.10e-2 23/30 (76.67%) GLUL;DLD;GRHPR;...
Proximal tubule bicarbonate reclamation 1.85 1.09e-2 21/23 (91.3%) CA2;PCK2;CA4;...
Phenylalanine metabolism 1.84 1.08e-2 14/17 (82.35%) MAOA;MAOB;AOC3;...
Parkinson disease 1.84 1.07e-2 176/249 (70.68%) MAOA;DUSP1;ATP5MC3;...
Arginine biosynthesis 1.82 1.29e-2 17/22 (77.27%) ASS1;GLUL;ASL;...
Adipocytokine signaling pathway 1.77 2.26e-2 64/69 (92.75%) NFKBIA;CPT1A;IRS2;...
Thermogenesis 1.76 2.11e-2 173/232 (74.57%) CPT1A;ACSL1;RPS6KA2;...
Nitrogen metabolism 1.76 2.04e-2 16/17 (94.12%) GLUL;CA2;CA12;...
Diabetic cardiomyopathy 1.73 2.38e-2 162/203 (79.8%) PDK4;TGFBR2;MPC1;...
Glycine, serine and threonine metabolism 1.72 2.58e-2 31/40 (77.5%) MAOA;CBS;MAOB;...
Tryptophan metabolism 1.72 2.71e-2 35/42 (83.33%) MAOA;AOX1;KYNU;...
Drug metabolism 1.71 2.87e-2 78/151 (51.66%) MAOA;AOX1;DUT;...
Small cell lung cancer 1.70 2.97e-2 90/92 (97.83%) NFKBIA;GADD45B;BIRC3;...
Insulin resistance 1.68 3.68e-2 96/108 (88.89%) NFKBIA;FOXO1;CPT1A;...
Peroxisome 1.66 4.08e-2 72/82 (87.8%) SOD2;PEX11A;ACSL1;...
Insulin signaling pathway 1.64 4.98e-2 121/137 (88.32%) FOXO1;IRS2;MKNK2;...
Viral protein interaction with cytokine and cytokine re... -1.93 2.03e-2 84/100 (84%) CCL27;CXCR2;CCL22;...
Rheumatoid arthritis -2.08 0.00e+0 78/93 (83.87%) TGFB3;CSF1;TGFB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H