Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTBFE4)

Drug Name
LY2090314 Drug Info
Synonyms
603288-22-8; LY-2090314; UNII-822M3GYM67; Kinome_3681; LY 2090314; CHEMBL362558; 822M3GYM67; 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione; SCHEMBL633455; GTPL7958; DTXSID90209085; MolPort-035-944-332; EX-A2214; ZINC3817327; BCP07855; s7063; BDBM50150699; AKOS032950045; AKOS026750195; CS-1633; DB11913; SB16558; NCGC00378942-05; NCGC00378942-02; BC600682; QC-11735; HY-16294; KB-78238; FT-0698670; LY2090314, &gt
Cross-matching ID
PubChem CID
10029385
ChEBI ID
CHEMBL362558
CAS Number
CAS 603288-22-8
TTD Drug ID
D0Z1DH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.20 0.00e+0 52/108 (48.15%) NOP56;DKC1;NAT10;...
RNA transport 2.13 0.00e+0 128/186 (68.82%) PABPC4;NDC1;EIF3B;...
Ribosome 1.97 1.89e-3 113/158 (71.52%) MRPS2;MRPL15;RPS5;...
Cysteine and methionine metabolism 1.92 4.25e-3 43/50 (86%) PSAT1;PHGDH;BCAT1;...
Alanine, aspartate and glutamate metabolism 1.85 1.13e-2 27/37 (72.97%) ASNS;ASS1;CAD;...
Aminoacyl-tRNA biosynthesis 1.73 2.93e-2 15/66 (22.73%) GATC;NARS2;QRSL1;...
Small cell lung cancer -1.69 4.94e-2 90/92 (97.83%) ITGA6;PIK3CB;BCL2;...
MAPK signaling pathway -1.73 3.46e-2 272/294 (92.52%) HSPA8;MAP3K6;MAP2K5;...
Leukocyte transendothelial migration -1.74 3.65e-2 90/114 (78.95%) CTNNB1;MAPK14;CLDN6;...
FoxO signaling pathway -1.80 2.28e-2 118/131 (90.08%) RBL2;AGAP2;MAPK11;...
PI3K-Akt signaling pathway -1.80 2.38e-2 317/354 (89.55%) EGFR;ITGA6;PIK3CB;...
Proteoglycans in cancer -1.80 2.34e-2 172/205 (83.9%) TP53;MAPK11;PLCE1;...
Bladder cancer -1.80 2.68e-2 40/41 (97.56%) TP53;TYMP;EGF;...
Apelin signaling pathway -1.86 1.56e-2 117/137 (85.4%) GNG7;RYR1;LIPE;...
Hematopoietic cell lineage -1.99 2.68e-3 90/99 (90.91%) CD8B;ITGA6;IL11RA;...
Amoebiasis -2.02 0.00e+0 99/102 (97.06%) LAMB2;CD1D;ARG1;...
Focal adhesion -2.07 0.00e+0 180/201 (89.55%) RAP1A;EGFR;ITGA6;...
ECM-receptor interaction -2.09 0.00e+0 80/88 (90.91%) ITGA6;ITGB1;ITGA4;...
Mineral absorption -2.15 0.00e+0 48/60 (80%) TF;CYBRD1;MT1M;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 3.33uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H