Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTCNOM)

Drug Name
Fasudil Drug Info
Synonyms
103745-39-7; HA1077; ha-1077; HA 1077; Fasudil [INN]; AT 877; Fasudilum [INN-Latin]; 1-(5-Isoquinolinesulfonyl)homopiperazine; 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-; UNII-Q0CH43PGXS; 5-(1,4-diazepane-1-sulfonyl)isoquinoline; 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline; (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE; AT-877; AT877; Q0CH43PGXS; 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE; CHEMBL38380; Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine; Fasudil (INN); Fasudilhydrochloride
Cross-matching ID
PubChem CID
3547
ChEBI ID
CHEMBL38380
CAS Number
CAS 103745-39-7
TTD Drug ID
D03KKR
VARIDT Drug ID
DR00792

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.28 0.00e+0 34/36 (94.44%) MCM6;PCNA;MCM5;...
Cell cycle 2.16 0.00e+0 110/124 (88.71%) MCM6;CCNB1;CDC20;...
Fanconi anemia pathway 2.08 0.00e+0 36/54 (66.67%) FANCL;REV1;RMI1;...
Mismatch repair 1.93 5.27e-3 22/23 (95.65%) PCNA;MSH2;RFC5;...
Ribosome 1.89 8.44e-3 113/158 (71.52%) RPL29;RPS5;MRPL19;...
Spliceosome 1.88 9.38e-3 101/150 (67.33%) LSM2;LSM3;LSM5;...
Nucleotide excision repair 1.81 2.11e-2 40/47 (85.11%) PCNA;RAD23B;RFC5;...
Homologous recombination 1.79 2.02e-2 35/41 (85.37%) RPA3;BRCC3;RAD51;...
Systemic lupus erythematosus 1.75 2.81e-2 45/135 (33.33%) HLA-DPB1;FCGR3B;CD40;...
Viral protein interaction with cytokine and cytokine re... 1.73 3.09e-2 84/100 (84%) CXCL9;CXCL12;CXCL10;...
Starch and sucrose metabolism 1.66 4.79e-2 25/36 (69.44%) UGP2;GPI;AGL;...
Amoebiasis -1.73 3.99e-2 99/102 (97.06%) GNA14;PIK3CA;MUC2;...
Kaposi sarcoma-associated herpesvirus infection -1.75 3.41e-2 172/193 (89.12%) CALML4;PIK3C3;PIK3CA;...
Pantothenate and CoA biosynthesis -1.78 2.71e-2 14/21 (66.67%) PANK3;BCAT1;ALDH2;...
Ferroptosis -1.80 2.44e-2 36/41 (87.8%) SLC39A14;MAP1LC3B;SLC39A8;...
Fluid shear stress and atherosclerosis -1.80 2.42e-2 123/139 (88.49%) ASS1;BMPR1B;KEAP1;...
Histidine metabolism -1.81 2.77e-2 16/22 (72.73%) HAL;ALDH3A1;ALDH3B1;...
Sphingolipid metabolism -1.82 2.58e-2 32/49 (65.31%) PSAP;SGMS1;KDSR;...
Epithelial cell signaling in Helicobacter pylori infect... -1.82 3.10e-2 62/70 (88.57%) ATP6V1F;MAPK13;NFKB1;...
Lysosome -1.83 3.55e-2 115/128 (89.84%) AP3S2;HYAL4;ATP6V0B;...
Thyroid hormone synthesis -1.89 2.58e-2 66/75 (88%) ALB;CREB3;DUOX1;...
Parathyroid hormone synthesis, secretion and action -2.09 0.00e+0 98/106 (92.45%) FOS;MAFB;ADCY8;...
Vibrio cholerae infection -2.15 0.00e+0 44/50 (88%) ATP6V1F;KDELR2;SEC61A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.02uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H