Details of the Drug Pharmacogenomic Perturbation Atlas

(+-)-tetrahydropalmatine Drug Info

Rotundine; Levo-thp (TN)

Cross-matching ID

PubChem CID

72301

ChEBI ID

CHEMBL487182

CAS Number

CAS 483-14-7

TTD Drug ID

D01FFA

General Information of Drug (ID: DMTCPDI)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome	2.24	0.00e+0	113/158 (71.52%)	RSL24D1;MRPL15;MRPL13;...
Oxidative phosphorylation	2.15	0.00e+0	93/133 (69.92%)	CYC1;ATP6V0B;SDHD;...
Parkinson disease	1.88	1.57e-2	176/249 (70.68%)	CYC1;CASP3;PSMC6;...
Diabetic cardiomyopathy	1.87	1.77e-2	162/203 (79.8%)	GAPDH;PLN;CYC1;...
Malaria	1.82	1.41e-2	44/50 (88%)	THBS1;CCL2;CD36;...
Thermogenesis	1.82	1.44e-2	173/232 (74.57%)	CYC1;GCG;CREB3L1;...
Huntington disease	1.82	1.23e-2	233/306 (76.14%)	POLR2I;CYC1;CASP8;...
Cardiac muscle contraction	1.77	1.67e-2	64/87 (73.56%)	CYC1;TNNC1;COX5B;...
Prion disease	1.74	2.09e-2	209/273 (76.56%)	HSPA8;HSPA2;CYC1;...
Riboflavin metabolism	1.72	2.51e-2	7/8 (87.5%)	ACP5;ACP1;RFK;...
DNA replication	1.68	3.92e-2	34/36 (94.44%)	POLE3;POLE2;RPA3;...
Intestinal immune network for IgA production	1.67	3.86e-2	38/48 (79.17%)	IL15;HLA-DQB1;TGFB1;...
Non-alcoholic fatty liver disease	1.67	3.74e-2	126/155 (81.29%)	CYC1;CASP8;CASP3;...
Phosphatidylinositol signaling system	-1.78	4.39e-2	82/97 (84.54%)	PIP4K2C;INPP4B;PIP5K1C;...
Carbohydrate digestion and absorption	-1.82	3.05e-2	37/47 (78.72%)	FXYD2;HK3;SLC2A2;...
Amoebiasis	-1.89	1.22e-2	99/102 (97.06%)	PLCB3;C9;TNF;...
Arginine biosynthesis	-1.93	1.22e-2	17/22 (77.27%)	NOS3;GLUD2;ARG1;...
Type II diabetes mellitus	-1.94	2.44e-2	42/46 (91.3%)	SOCS1;IKBKB;ABCC8;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H

Bone marrow

Neuroblastoma

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H