Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTFGYH)

Drug Name
Org-231295 Drug Info
Synonyms
3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate; 546141-08-6; URB597; URB-597; URB 597; FAAH Inhibitor II; KDS-4103; UNII-PX47LB88FO; 3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate; PX47LB88FO; CHEMBL184238; 3'-Carbamoylbiphenyl-3-yl cyclohexylcarbamate; [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate; Carbamic acid, N-cyclohexyl-, 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester; Cyclohexyl-carbamic acid 3'-carbamoyl-biphenyl-3-yl ester; KDS-1243; FAAH inhibitor, Merck & Co; FAAH inhibitor, Schering-Plough/Kadmus/university of California; 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
Cross-matching ID
PubChem CID
1383884
ChEBI ID
CHEMBL184238
CAS Number
CAS 546141-08-6
TTD Drug ID
D0NH1E

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid hormone biosynthesis 2.15 0.00e+0 43/61 (70.49%) AKR1C2;AKR1C1;AKR1C3;...
Tuberculosis 2.01 0.00e+0 159/180 (88.33%) CASP10;HLA-DQA1;CD14;...
p53 signaling pathway 1.99 3.74e-3 63/73 (86.3%) CCNB1;SERPINB5;SFN;...
NF-kappa B signaling pathway 1.95 5.60e-3 90/104 (86.54%) RELB;CD14;PLCG2;...
Staphylococcus aureus infection 1.94 4.48e-3 72/95 (75.79%) HLA-DQA1;FPR1;KRT14;...
Osteoclast differentiation 1.91 3.74e-3 117/127 (92.13%) RELB;MAP2K6;PLCG2;...
Legionellosis 1.83 1.44e-2 51/57 (89.47%) HSPA6;CD14;TLR2;...
IL-17 signaling pathway 1.82 1.26e-2 84/94 (89.36%) S100A9;S100A8;LCN2;...
Sulfur metabolism 1.81 1.49e-2 9/10 (90%) PAPSS2;TST;SQOR;...
Rheumatoid arthritis 1.80 1.46e-2 78/93 (83.87%) CCL20;HLA-DQA1;TLR2;...
C-type lectin receptor signaling pathway 1.78 1.43e-2 93/104 (89.42%) RELB;CLEC7A;PLCG2;...
Toxoplasmosis 1.73 2.15e-2 103/112 (91.96%) LAMC2;HLA-DQA1;HSPA6;...
Steroid biosynthesis 1.70 3.36e-2 19/20 (95%) HSD17B7;SQLE;SC5D;...
PD-L1 expression and PD-1 checkpoint pathway in cancer 1.68 4.32e-2 79/89 (88.76%) MAP2K6;TLR2;TLR4;...
Proteasome 1.68 4.11e-2 44/46 (95.65%) PSMD1;PSMB3;PSMD11;...
Folate biosynthesis 1.66 4.55e-2 23/26 (88.46%) AKR1B10;AKR1C3;CBR1;...
Metabolism of xenobiotics by cytochrome P450 1.66 4.35e-2 49/77 (63.64%) AKR1C1;CYP1B1;GSTA4;...
Th1 and Th2 cell differentiation 1.65 4.61e-2 80/92 (86.96%) HLA-DQA1;PRKCQ;MAPK13;...
Leishmaniasis 1.65 4.78e-2 67/77 (87.01%) HLA-DQA1;TLR2;NCF2;...
Natural killer cell mediated cytotoxicity 1.64 4.82e-2 99/131 (75.57%) PLCG2;ICAM2;LCK;...
Glutamatergic synapse -1.73 2.98e-2 97/114 (85.09%) ADCY2;ADCY3;PLCB1;...
Aldosterone synthesis and secretion -1.75 2.92e-2 85/98 (86.73%) CAMK2B;PLCB4;CREB3L2;...
Morphine addiction -1.77 2.41e-2 80/91 (87.91%) ADCY2;ADCY3;KCNJ6;...
Nicotine addiction -1.78 2.75e-2 32/40 (80%) GABRA6;GABRE;GABRA5;...
Insulin secretion -1.79 2.92e-2 75/86 (87.21%) CAMK2B;RIMS2;PLCB4;...
Hedgehog signaling pathway -1.81 2.80e-2 43/56 (76.79%) SCUBE2;GRK2;CSNK1G3;...
Cortisol synthesis and secretion -1.82 3.28e-2 58/65 (89.23%) PLCB4;CREB3L2;GNAQ;...
Circadian entrainment -1.83 4.08e-2 85/97 (87.63%) GRIN2C;GNAI2;GRIA4;...
GABAergic synapse -1.86 2.19e-2 76/89 (85.39%) GABRD;SLC6A1;GNG3;...
Proximal tubule bicarbonate reclamation -1.88 4.38e-2 21/23 (91.3%) CA4;ATP1A3;ATP1B3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H