Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTGMB1)

Drug Name
Metanephrine Drug Info
Synonyms
Metanephrine; Metadrenaline; 5001-33-2; DL-Metanephrine; 3-Methoxyadrenaline; m-O-Methyladrenaline; (+/-)-Metanephrine; 4-[1-Hydroxy-2-(methylamino)ethyl]-2-methoxyphenol; CHEBI:89633; JWJCTZKFYGDABJ-UHFFFAOYSA-N; 3-methoxy-adrenaline; epinephrine metabolite; 3-O-Methylepinephrine; 3-O-methyl-Adrenaline; Adrenaline, 3-methoxy-; AC1L2HML; Prestwick2_000122; Prestwick0_000122; DL-3-O-Methyladrenaline; Prestwick3_000122; Prestwick1_000122; Adrenaline, 3-O-methyl-; DL-METANEPHRINE HCI; CHEMBL775; Vanillyl alcohol, .alpha.-[(methylamin
Cross-matching ID
PubChem CID
21100
ChEBI ID
CHEMBL89633
CAS Number
CAS 5001-33-2
TTD Drug ID
D03HKV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.28 0.00e+0 48/60 (80%) SLC26A3;MT1X;MT1F;...
Ascorbate and aldarate metabolism 2.04 0.00e+0 15/30 (50%) UGT2B17;GUSB;UGT2B15;...
Ribosome biogenesis in eukaryotes 2.00 0.00e+0 52/108 (48.15%) RPP40;REXO2;NOP56;...
Cysteine and methionine metabolism 1.80 1.19e-2 43/50 (86%) TST;MPST;CTH;...
Pentose and glucuronate interconversions 1.80 9.55e-3 17/34 (50%) UGT2B17;AKR1B10;GUSB;...
Porphyrin and chlorophyll metabolism 1.80 7.96e-3 23/43 (53.49%) UGT2B17;HMOX2;GUSB;...
Galactose metabolism 1.74 2.14e-2 26/31 (83.87%) HK2;GLA;MGAM;...
Drug metabolism 1.71 2.73e-2 78/151 (51.66%) MAOB;GSTM3;UGT2B17;...
RNA polymerase 1.70 2.96e-2 23/31 (74.19%) POLR3G;POLR2F;POLR3E;...
Hypertrophic cardiomyopathy -2.08 0.00e+0 81/90 (90%) SGCB;TGFB3;CACNB2;...
Dilated cardiomyopathy -2.18 0.00e+0 86/96 (89.58%) ITGB5;ITGB6;ACTB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 8uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H