Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTGU6K)

Drug Name
REN-1654 Drug Info
Synonyms Antineurodegeneratives, Centaur; CPI-1160; CPI-1189; Parkinsons therapy, Centaur; REN-1189
Cross-matching ID
PubChem CID
151118
CAS Number
CAS 183619-38-7
TTD Drug ID
D0B5RO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Parkinson disease 2.08 0.00e+0 176/249 (70.68%) SNCA;TXN;PRKACB;...
DNA replication 2.02 0.00e+0 34/36 (94.44%) POLE3;PCNA;POLE2;...
Oxidative phosphorylation 1.94 6.07e-3 93/133 (69.92%) PPA1;ATP6V1D;ATP6V1G1;...
Proteasome 1.86 1.59e-2 44/46 (95.65%) PSMA2;PSMD11;PSMD14;...
Ribosome 1.84 1.82e-2 113/158 (71.52%) MRPS18A;MRPL13;MRPL19;...
Nucleotide excision repair 1.81 1.82e-2 40/47 (85.11%) POLE3;PCNA;MNAT1;...
Purine metabolism 1.77 3.12e-2 102/129 (79.07%) NME4;AK4;PAPSS2;...
Pyrimidine metabolism 1.74 3.53e-2 40/56 (71.43%) NME4;NME1;DCK;...
Prion disease 1.73 3.44e-2 209/273 (76.56%) PRKACB;PSMA2;PSMD11;...
Huntington disease 1.72 3.09e-2 233/306 (76.14%) POLR2I;PSMA2;PSMD11;...
Porphyrin and chlorophyll metabolism 1.70 3.47e-2 23/43 (53.49%) CP;FXN;ALAS2;...
Thermogenesis 1.70 3.26e-2 173/232 (74.57%) CNR1;PRKACB;NDUFA8;...
Olfactory transduction 1.69 3.22e-2 69/440 (15.68%) PRKACB;CALML5;RGS2;...
MicroRNAs in cancer -1.77 3.44e-2 146/310 (47.1%) MCL1;MAP2K2;PIK3CB;...
Basal cell carcinoma -1.77 4.13e-2 41/63 (65.08%) BMP4;DDB2;APC2;...
ABC transporters -1.78 4.89e-2 37/45 (82.22%) ABCD3;ABCB1;ABCC9;...
Citrate cycle (TCA cycle) -1.80 4.35e-2 30/30 (100%) IDH1;FH;SUCLG2;...
Herpes simplex virus 1 infection -1.94 0.00e+0 165/498 (33.13%) HLA-DRB1;IFNAR2;PPP1CC;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H