Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTHB2Y)

Drug Name
nTzDpa Drug Info
Synonyms
nTzDpa; 118414-59-8; 5-Chloro-1-(4-Chlorobenzyl)-3-(Phenylthio)-1h-Indole-2-Carboxylic Acid; 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID; CHEMBL370152; 1H-Indole-2-carboxylicacid, 5-chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-; NZA; ACMC-1CBOZ; SCHEMBL6709652; GTPL2699; CTK0H3131; DTXSID40433292; MolPort-003-983-790; HMS3268N03; ZINC1492396; BDBM50173365; BS0133; AKOS024456957; NCGC00092313-01; RT-014770; KB-245430; B6955; J-003750; BRD-K54708045-001-01-3
Cross-matching ID
PubChem CID
9954280
ChEBI ID
CHEMBL370152
CAS Number
CAS 118414-59-8
TTD Drug ID
D08QKF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RNA degradation 1.86 4.33e-2 53/79 (67.09%) LSM5;EXOSC4;PFKM;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.84 3.61e-2 9/11 (81.82%) NQO1;COQ2;VKORC1
Adherens junction -1.71 4.47e-2 63/71 (88.73%) WAS;MAP3K7;CDC42;...
Complement and coagulation cascades -1.77 2.46e-2 76/85 (89.41%) PLAT;ITGAX;F2R;...
Steroid hormone biosynthesis -1.77 2.73e-2 43/61 (70.49%) AKR1D1;DHRS11;AKR1C4;...
Bile secretion -1.79 2.43e-2 68/90 (75.56%) ATP1B3;NR1H4;SLC10A1;...
Proteasome -1.80 2.22e-2 44/46 (95.65%) PSMA7;PSMC5;PSMD11;...
Retinol metabolism -1.80 2.37e-2 41/68 (60.29%) CYP2C9;ALDH1A1;RDH11;...
Phagosome -1.87 1.04e-2 118/152 (77.63%) FCGR2C;C1R;DYNC1LI2;...
Protein processing in endoplasmic reticulum -1.89 1.30e-2 127/171 (74.27%) EDEM3;VCP;SEC13;...
Ascorbate and aldarate metabolism -1.90 1.73e-2 15/30 (50%) ALDH2;RGN;UGT2B17;...
Antigen processing and presentation -2.02 0.00e+0 60/78 (76.92%) IFNG;LGMN;CD4;...
Steroid biosynthesis -2.15 0.00e+0 19/20 (95%) SC5D;CYP51A1;SOAT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H