Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTIGA0)

• Drug Name: Acrivastine Drug Info
• Synonyms: Acrivastin; Acrivastina; Acrivastinum; Semprex; Acrivastina [Spanish]; Acrivastinum [Latin]; Benadryl allergy relief; BW 0270C; BW 825C; BW A825C; BW-825C; Acrivastine (USAN/INN); Acrivastine [USAN:INN:BAN]; E-(9CI); (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid; (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid; (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid; (E)-6-((E)-3-(1-Pyrrolidinyl-1-p-tolylpropenyl)-2-pyridinacrylsaeure; (E,E)-3-[6-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-2-propenoic acid; 3-{6-[1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid
• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 5284514
  ChEBI ID: CHEMBL83168
  CAS Number: CAS 87848-99-5
  TTD Drug ID: D0O4EU
  VARIDT Drug ID: DR01418

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome biogenesis in eukaryotes	2.21	6.03e-3	52/108 (48.15%)	NVL;NOP56;GTPBP4;...
Base excision repair	1.91	6.03e-3	29/33 (87.88%)	PCNA;POLE2;APEX1;...
DNA replication	1.91	4.02e-3	34/36 (94.44%)	PCNA;POLE2;FEN1;...
Complement and coagulation cascades	1.79	1.81e-2	76/85 (89.41%)	SERPING1;C1QB;A2M;...
Pentose phosphate pathway	-1.68	4.95e-2	25/30 (83.33%)	PFKP;PGLS;TKT;...
Other glycan degradation	-1.70	4.79e-2	13/18 (72.22%)	GLB1;HEXB;NEU1;...
NF-kappa B signaling pathway	-1.70	4.85e-2	90/104 (86.54%)	IKBKB;TNF;TRIM25;...
Parathyroid hormone synthesis, secretion and action	-1.72	4.07e-2	98/106 (92.45%)	MEF2A;HBEGF;KL;...
Natural killer cell mediated cytotoxicity	-1.73	4.00e-2	99/131 (75.57%)	PIK3R3;PIK3R2;SHC3;...
Th1 and Th2 cell differentiation	-1.73	4.31e-2	80/92 (86.96%)	IFNGR1;FOS;IKBKB;...
Mitophagy	-1.73	4.56e-2	56/68 (82.35%)	FOXO3;CALCOCO2;PINK1;...
T cell receptor signaling pathway	-1.74	4.51e-2	93/104 (89.42%)	FOS;DLG1;PIK3CB;...
Epstein-Barr virus infection	-1.74	4.71e-2	189/202 (93.56%)	PIK3CB;IKBKB;OAS1;...
B cell receptor signaling pathway	-1.75	4.77e-2	71/81 (87.65%)	FOS;PIK3CB;GSK3B;...
Mineral absorption	-1.80	3.82e-2	48/60 (80%)	FTL;ATP1B2;SLC11A2;...
Hepatitis C	-1.80	4.77e-2	139/157 (88.54%)	IRF7;YWHAH;PIK3CB;...
Leukocyte transendothelial migration	-1.93	3.82e-2	90/114 (78.95%)	CYBA;MYL9;ACTN4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼