Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTIVEN)

Drug Name
Metronidazole Drug Info
Synonyms
APMN; Acromona; Anagiardil; Arilin; Atrivyl; Bexon; CONT; Clont; Danizol; Deflamon; Efloran; Elyzol; Entizol; Eumin; Flagemona; Flagesol; Flagil; Flagyl; Flegyl; Florazole; Fossyol; Giatricol; Gineflavir; Giniflavir; Klion; Klont; Meronidal; Methronidazole; Metric; MetroCream; MetroGel; MetroLotion; Metrodzhil; Metrogyl; Metrolag; Metrolyl; Metromidol; Metronidaz; Metronidazol; Metronidazolo; Metronidazolum; Metrotop; Metrozine; Metryl; Mexibol; Monagyl; Monasin; NIDA; Nalox; Nidagel; Noritate; Novonidazol; Orvagil; Protostat; Rathimed; Rosased; Sanatrichom; Satric; Takimetol; Trichazol; Trichex; Trichocide; Trichomol; Trichopal; Trichopol; Tricocet; Tricom; Trikacide; Trikamon; Trikojol; Trikozol; Trimeks; Trivazol; Vagilen; Vagimid; Vandazole; Vertisal; Wagitran; Zadstat; Zidoval; Flagyl Er; Ginefla vir; METRONIDAZOLE USP; Metro Cream; Metro Gel; Metronidazole Monohydrochloride; Metronidazole Phosphoester; Metronidazole in Plastic Container; Metronidazolo [DCIT]; Tricho cordes; Trichomonacid pharmachim; Tricowas B; Bayer 5360; Flagyl 375; M0924; Metric 21; RP 8823; SC 10295; Anabact (TN); Apo-Metronidazole; Deflamon-wirkstoff; Flagyl (TN); IDR-90105; METRO I.V; MetroGel (TN); MetroGel-Vaginal; Metronidazol [INN-Spanish]; Metronidazolum [INN-Latin]; Mexibol (silanes); Neo-Tric; Noritate (TN); RP-8823; Rozex (TN); Tricho-gynaedron; ZERO/004064; CB-01-14 MMX; FLAGYL I.V. RTU IN PLASTIC CONTAINER; Flagyl I.V.; Flagyl I.V. RTU; Metro I.V.; Metro I.V. In Plastic Container; Metrogel-vaginal (TN); Metronidazole (JP15/USP/INN); Metronidazole [USAN:INN:BAN:JAN]; Methyl-5-nitroimidazole-1-ethanol; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2-(2-methyl-5-nitroimidazol-1-yl)ethanol; 2-Methyl-5-nitro-1-imidazoleethanol; 2-Methyl-5-nitroimidazole-1-ethanol; MNZ
Therapeutic ClassAntiinfective Agents
Cross-matching ID
PubChem CID
4173
ChEBI ID
CHEMBL137
CAS Number
CAS 443-48-1
TTD Drug ID
D0A2ZX
INTEDE Drug ID
DR1073
ACDINA Drug ID
D00425

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.29 0.00e+0 44/46 (95.65%) PSMC4;PSMD13;PSMD12;...
Epithelial cell signaling in Helicobacter pylori infect... 1.95 0.00e+0 62/70 (88.57%) CXCL2;SRC;CXCL3;...
Kaposi sarcoma-associated herpesvirus infection 1.83 1.89e-2 172/193 (89.12%) CXCL2;SRC;GNG11;...
Ribosome biogenesis in eukaryotes 1.76 4.77e-2 52/108 (48.15%) NVL;GTPBP4;NAT10;...
Basal transcription factors 1.75 4.35e-2 37/45 (82.22%) MNAT1;GTF2IRD1;GTF2E2;...
TNF signaling pathway 1.75 3.73e-2 103/112 (91.96%) CXCL2;CXCL3;CXCL1;...
Hedgehog signaling pathway 1.73 4.26e-2 43/56 (76.79%) CCND1;GLI2;EVC;...
Cytosolic DNA-sensing pathway 1.69 5.00e-2 52/63 (82.54%) IL6;AIM2;IL1B;...
IL-17 signaling pathway 1.69 4.96e-2 84/94 (89.36%) CXCL2;CXCL3;CXCL1;...
Sulfur relay system -1.62 4.77e-2 5/8 (62.5%) MOCS2;MPST;TST
Pancreatic secretion -1.63 4.68e-2 87/102 (85.29%) ADCY9;CPB2;ATP1B2;...
Propanoate metabolism -1.64 4.49e-2 30/34 (88.24%) ACACA;LDHA;EHHADH;...
Porphyrin and chlorophyll metabolism -1.66 3.85e-2 23/43 (53.49%) HMBS;FECH;UGT2B17;...
Cardiac muscle contraction -1.68 3.69e-2 64/87 (73.56%) COX5A;ATP1B2;COX6A1;...
Drug metabolism -1.68 3.81e-2 78/151 (51.66%) CYP2C9;CDA;FMO4;...
Insulin secretion -1.68 3.96e-2 75/86 (87.21%) PLCB2;CREB3L2;ADCY9;...
Taurine and hypotaurine metabolism -1.70 3.42e-2 8/11 (72.73%) ADO;GGT5;GAD1
Tryptophan metabolism -1.78 1.66e-2 35/42 (83.33%) ALDH8A1;EHHADH;ALDH7A1;...
Oxidative phosphorylation -1.81 1.32e-2 93/133 (69.92%) NDUFA10;NDUFS7;TCIRG1;...
Diabetic cardiomyopathy -1.83 1.27e-2 162/203 (79.8%) PPP1CA;RAC1;MAPK11;...
Bile secretion -1.83 1.11e-2 68/90 (75.56%) ADCY9;UGT2B17;ATP1B2;...
Sulfur metabolism -1.87 7.94e-3 9/10 (90%) MPST;ETHE1;TST;...
Ascorbate and aldarate metabolism -1.89 7.78e-3 15/30 (50%) UGDH;ALDH7A1;ALDH1B1;...
Proximal tubule bicarbonate reclamation -1.90 9.08e-3 21/23 (91.3%) CA4;PCK2;ATP1B2;...
Butanoate metabolism -1.93 1.09e-2 23/28 (82.14%) EHHADH;AACS;ECHS1;...
Mineral absorption -2.02 4.54e-3 48/60 (80%) ATP1B2;HEPH;TF;...
Glycine, serine and threonine metabolism -2.03 6.05e-3 31/40 (77.5%) GRHPR;ALDH7A1;GNMT;...
Valine, leucine and isoleucine degradation -2.10 0.00e+0 42/48 (87.5%) ALDH7A1;AACS;BCKDHB;...
Glyoxylate and dicarboxylate metabolism -2.11 0.00e+0 23/30 (76.67%) HYI;ACO1;GRHPR;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 12uM - 100uM 48H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 100uM 3H, 24H, 48H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 20uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H