Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTJOWH)

Drug Name
CP-339818 Drug Info
Synonyms
CHEMBL281622; AC1LCVJB; CP 339818; Tocris-1399; C13847; (1-Benzyl-1H-quinolin-4-ylidene)-pentyl-amine; SureCN12648579; GTPL2558; SCHEMBL12648579; CHEBI:34602; 1-benzyl-N-pentylquinolin-4-imine; 1-benzyl-N-pentyl-quinolin-4-imine; ZINC17919916; BDBM50083523; ZINC100002080; ZINC253533285; NCGC00025144-01; AJ-70179; CP339818; AJ-70180; N-pentyl-1-(phenylmethyl)quinolin-4-imine
Cross-matching ID
PubChem CID
656767
ChEBI ID
CHEMBL34602
CAS Number
CAS 185855-91-8
TTD Drug ID
D0E9MC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.35 0.00e+0 48/60 (80%) MT1F;MT1H;MT1E;...
Glycine, serine and threonine metabolism 2.20 0.00e+0 31/40 (77.5%) PSAT1;CTH;CBS;...
Retinol metabolism 2.09 0.00e+0 41/68 (60.29%) UGT2B15;UGT2B28;ADH1C;...
Cysteine and methionine metabolism 2.00 1.96e-3 43/50 (86%) PSAT1;CTH;CBS;...
Porphyrin and chlorophyll metabolism 1.94 1.57e-3 23/43 (53.49%) CP;HMOX1;UGT2B15;...
Tyrosine metabolism 1.93 2.61e-3 30/36 (83.33%) ADH1C;ADH1B;GOT1;...
Pentose and glucuronate interconversions 1.93 2.24e-3 17/34 (50%) SORD;UGT2B15;AKR1B10;...
Metabolism of xenobiotics by cytochrome P450 1.92 1.96e-3 49/77 (63.64%) UGT2B15;UGT2B28;ADH1C;...
Ferroptosis 1.91 1.74e-3 36/41 (87.8%) SLC7A11;CP;SLC39A14;...
Steroid hormone biosynthesis 1.88 3.13e-3 43/61 (70.49%) UGT2B15;UGT2B28;HSD17B2;...
Arginine biosynthesis 1.86 4.98e-3 17/22 (77.27%) ASS1;CPS1;GOT1;...
Primary bile acid biosynthesis 1.85 4.57e-3 15/17 (88.24%) HSD17B4;AMACR;CYP39A1;...
Ascorbate and aldarate metabolism 1.78 1.08e-2 15/30 (50%) UGT2B15;UGT2B28;UGT2B17;...
Complement and coagulation cascades 1.73 1.79e-2 76/85 (89.41%) TFPI;CFH;CFB;...
Bile secretion 1.72 1.93e-2 68/90 (75.56%) SLCO1B3;UGT2B15;UGT2B28;...
Alanine, aspartate and glutamate metabolism 1.70 2.06e-2 27/37 (72.97%) ASS1;ASNS;CPS1;...
T cell receptor signaling pathway -1.83 3.29e-2 93/104 (89.42%) AKT3;MAP3K8;CD40LG;...
Neutrophil extracellular trap formation -1.85 3.70e-2 101/189 (53.44%) TLR4;MPO;AKT2;...
Fc epsilon RI signaling pathway -2.10 0.00e+0 57/68 (83.82%) MAP2K4;MAPK9;PIK3CA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 3.33uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 3.33uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H