Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTK4LS)

Drug Name
Triptorelin Drug Info
Synonyms Gonapeptyl depot (TN)
Cross-matching ID
PubChem CID
25074470
ChEBI ID
CHEMBL63633
CAS Number
CAS 57773-63-4
TTD Drug ID
D03QRS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.12 0.00e+0 34/36 (94.44%) PRIM1;RPA3;MCM7;...
One carbon pool by folate 1.98 4.74e-3 15/20 (75%) DHFR;MTHFD1;TYMS;...
Citrate cycle (TCA cycle) 1.91 3.16e-3 30/30 (100%) DLD;IDH2;SUCLG2;...
Mismatch repair 1.83 2.13e-2 22/23 (95.65%) RPA3;RFC5;EXO1;...
Tyrosine metabolism 1.75 4.36e-2 30/36 (83.33%) TYRP1;ALDH3A1;FAH;...
Homologous recombination 1.74 3.79e-2 35/41 (85.37%) RAD51;BRCA1;RPA3;...
Rheumatoid arthritis -1.72 3.95e-2 78/93 (83.87%) ANGPT1;TNFSF13;IL18;...
Phagosome -1.77 2.11e-2 118/152 (77.63%) HLA-B;SEC61B;SEC61A2;...
Lysosome -1.78 2.28e-2 115/128 (89.84%) ABCA2;CLTC;HYAL2;...
Graft-versus-host disease -1.86 4.22e-3 32/42 (76.19%) HLA-G;HLA-B;FAS;...
Autoimmune thyroid disease -1.94 2.64e-3 46/53 (86.79%) FAS;CGA;HLA-C;...
Allograft rejection -2.06 3.52e-3 32/38 (84.21%) PRF1;CD86;HLA-DOA;...
Asthma -2.07 5.27e-3 25/31 (80.65%) FCER1G;HLA-DOA;MS4A2;...
Steroid biosynthesis -2.08 1.05e-2 19/20 (95%) HSD17B7;CYP27B1;LSS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H