Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTMNO7)

Drug Name
7-hydroxycoumarin Drug Info
Synonyms
Umbelliferone; 93-35-6; 7-Hydroxy-2H-chromen-2-one; Skimmetin; Hydrangin; 7-hydroxycoumarine; 7-Oxycoumarin; Umbelliferon; Skimmetine; Hydrangine; 2H-1-Benzopyran-2-one, 7-hydroxy-; 7-Hydroxy-2H-1-benzopyran-2-one; Coumarin, 7-hydroxy-; beta-Umbelliferone; 7-hydroxychromen-2-one; 7 HC; UNII-60Z60NTL4G; 7-hydroxy-coumarin; NSC 19790; CCRIS 3591; NSC19790; EINECS 202-240-3; 7H-1-Benzopyran-7-one, 2-hydroxy-; BRN 0127683; CHEMBL51628; AI3-38054; 7-hydroxy-1-benzopyran-2-one; 7-HC; 60Z60NTL4G; CHEBI:27510; UMBELLIFERONE
Cross-matching ID
PubChem CID
5281426
ChEBI ID
CHEMBL51628
CAS Number
CAS 93-35-6
TTD Drug ID
D02JEZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.02 0.00e+0 34/36 (94.44%) POLE3;RFC4;MCM5;...
Proteasome 1.93 9.61e-3 44/46 (95.65%) PSMA1;PSMA6;PSMA7;...
Malaria -1.64 4.91e-2 44/50 (88%) KLRB1;GYPC;CCL2;...
Renin-angiotensin system -1.65 4.89e-2 20/23 (86.96%) KLK2;ANPEP;CTSA;...
Histidine metabolism -1.66 4.93e-2 16/22 (72.73%) ALDH2;CNDP2;MAOB;...
Porphyrin and chlorophyll metabolism -1.67 4.90e-2 23/43 (53.49%) GUSB;UGT2A3;BLVRB;...
Legionellosis -1.70 4.05e-2 51/57 (89.47%) CD14;HSPA1A;TNF;...
Type I diabetes mellitus -1.70 4.26e-2 38/43 (88.37%) HLA-C;HLA-DQB1;HLA-F;...
Antigen processing and presentation -1.70 4.41e-2 60/78 (76.92%) CIITA;HLA-B;HSPA1A;...
Protein export -1.78 3.53e-2 17/23 (73.91%) SRPRB;SEC61A1;SPCS1;...
IL-17 signaling pathway -1.83 3.11e-2 84/94 (89.36%) IKBKB;CASP3;TAB2;...
PPAR signaling pathway -1.84 4.15e-2 66/74 (89.19%) SCD5;PPARA;GK2;...
Peroxisome -1.87 3.63e-2 72/82 (87.8%) ACSL6;PEX3;HAO2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H