Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTMVYH)

Drug Name
ZM-39923 Drug Info
Synonyms
ZM39923; 273727-89-2; ZM-39923; UNII-M0ZX82000S; M0ZX82000S; 3-[benzyl(propan-2-yl)amino]-1-(naphthalen-2-yl)propan-1-one; 3-(Benzyl(propan-2-yl)amino)-1-(naphthalen-2-yl)propan-1-one; JSASWRWALCMOQP-UHFFFAOYSA-N; Tocris-1367; NCGC00025126-01; AC1L1GQH; Lopac-Z-4626; Lopac0_000844; SCHEMBL2891331; GTPL5994; CHEMBL596674; CHEBI:92715; BDBM81346; CTK6A9359; M9440 (Me-3,4-dephostatin); ZINC1487934; HY-12589A; HSCI1_000104; AKOS030526763; CS-4952; CCG-204927; NCGC00025126-02; NCGC00016107-05; NCGC00016107-02; NCGC00016107-09
Cross-matching ID
PubChem CID
3797
ChEBI ID
CHEMBL596674
CAS Number
CAS 273727-89-2
TTD Drug ID
D0YX5U

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Chemokine signaling pathway 2.09 0.00e+0 163/192 (84.9%) CXCL13;CXCL9;CXCL2;...
DNA replication 2.03 0.00e+0 34/36 (94.44%) PCNA;SSBP1;POLE3;...
NF-kappa B signaling pathway 2.02 0.00e+0 90/104 (86.54%) VCAM1;CD40;CXCL2;...
Spliceosome 1.98 0.00e+0 101/150 (67.33%) HSPA6;HSPA8;HSPA1A;...
HIF-1 signaling pathway 1.97 0.00e+0 105/109 (96.33%) HMOX1;TFRC;HK2;...
Antigen processing and presentation 1.93 0.00e+0 60/78 (76.92%) HSPA6;HSPA8;HSPA4;...
Legionellosis 1.90 1.99e-3 51/57 (89.47%) CXCL2;HSPA6;HSPA8;...
Viral protein interaction with cytokine and cytokine re... 1.87 5.21e-3 84/100 (84%) CXCL13;CXCL9;CXCL2;...
Leishmaniasis 1.85 7.72e-3 67/77 (87.01%) PTPN6;CYBB;TGFB1;...
Salivary secretion 1.84 8.34e-3 76/93 (81.72%) LYZ;GNAS;FXYD2;...
Malaria 1.83 8.85e-3 44/50 (88%) VCAM1;CD40;TGFB1;...
Toxoplasmosis 1.82 1.04e-2 103/112 (91.96%) CD40;HSPA6;HSPA8;...
IL-17 signaling pathway 1.80 1.39e-2 84/94 (89.36%) CXCL2;MMP9;CXCL8;...
RNA transport 1.80 1.29e-2 128/186 (68.82%) RNPS1;EIF4G1;RAN;...
TNF signaling pathway 1.79 1.39e-2 103/112 (91.96%) VCAM1;CXCL2;MMP9;...
Ribosome biogenesis in eukaryotes 1.74 2.52e-2 52/108 (48.15%) RAN;FBL;GAR1;...
Primary immunodeficiency 1.73 2.45e-2 33/38 (86.84%) CD40;IL7R;DCLRE1C;...
Estrogen signaling pathway 1.71 2.86e-2 119/137 (86.86%) HSPA6;KRT17;HSPA8;...
B cell receptor signaling pathway 1.71 2.93e-2 71/81 (87.65%) PTPN6;NFKB1;PIK3CB;...
Fc gamma R-mediated phagocytosis 1.70 2.92e-2 79/97 (81.44%) HCK;MARCKS;SPHK1;...
Longevity regulating pathway 1.69 3.05e-2 90/151 (59.6%) HSPA6;HSPA8;SOD2;...
Central carbon metabolism in cancer 1.68 3.03e-2 67/70 (95.71%) PGAM1;HK2;PFKP;...
Lipid and atherosclerosis 1.68 3.08e-2 190/215 (88.37%) VCAM1;CD40;CXCL2;...
Type II diabetes mellitus 1.66 3.77e-2 42/46 (91.3%) HK2;PKM;PIK3CB;...
Base excision repair 1.65 4.06e-2 29/33 (87.88%) PCNA;POLE3;SMUG1;...
Renal cell carcinoma 1.65 4.01e-2 68/69 (98.55%) ARNT2;VEGFA;TGFB1;...
Cortisol synthesis and secretion 1.64 4.02e-2 58/65 (89.23%) GNAS;NR4A1;STAR;...
Non-homologous end-joining 1.61 4.92e-2 11/13 (84.62%) PRKDC;DCLRE1C;FEN1;...
Fatty acid degradation -1.64 4.04e-2 40/43 (93.02%) ACADS;ACSL4;ADH5;...
Peroxisome -1.71 1.78e-2 72/82 (87.8%) NOS2;HAO2;ECH1;...
Tyrosine metabolism -1.84 4.60e-3 30/36 (83.33%) ALDH3B1;TAT;TYR;...
Sulfur metabolism -1.84 5.18e-3 9/10 (90%) SELENBP1;SQOR;ETHE1;...
Ribosome -1.87 1.69e-3 113/158 (71.52%) RPL39;MRPS14;RPLP1;...
Metabolism of xenobiotics by cytochrome P450 -1.87 1.97e-3 49/77 (63.64%) AKR1C1;CYP2B6;CYP2D6;...
Steroid hormone biosynthesis -1.94 1.18e-3 43/61 (70.49%) AKR1C4;SRD5A1;CYP19A1;...
Retinol metabolism -1.98 0.00e+0 41/68 (60.29%) CYP2B6;CYP2A6;BCO1;...
Drug metabolism -1.99 0.00e+0 78/151 (51.66%) IMPDH2;ALDH3B1;NME7;...
Primary bile acid biosynthesis -2.01 0.00e+0 15/17 (88.24%) CYP46A1;SLC27A5;AKR1D1;...
Oxidative phosphorylation -2.04 0.00e+0 93/133 (69.92%) NDUFS3;COX11;LHPP;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H