Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTPRBX)

Drug Name
CGI-1316 Drug Info
Synonyms
CGI-1746; CGI-2233; CGI-2815; CGI-3130; CGI-560; CGI-676; Btk inhibitors (autoimmune disease/inflammatory disease); Btk inhibitors (autoimmune disease/inflammatory disease), CGI Pharmaceuticals; Btk inhibitors (autoimmune disease/inflammatory disease), Cellular Genomics; Btk inhibitors (autoimmune disease/inflammatory disease), Gilead
Cross-matching ID
PubChem CID
24857323
ChEBI ID
CHEMBL1230541
CAS Number
CAS 910232-84-7
TTD Drug ID
D0H3JH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.11 0.00e+0 31/40 (77.5%) PSAT1;PHGDH;SHMT2;...
Pentose and glucuronate interconversions 2.06 0.00e+0 17/34 (50%) AKR1B1;DCXR;AKR1B10;...
Cysteine and methionine metabolism 1.90 1.59e-2 43/50 (86%) PSAT1;PHGDH;BCAT1;...
Arginine and proline metabolism 1.89 2.38e-2 39/50 (78%) PYCR1;GOT1;ODC1;...
One carbon pool by folate 1.87 2.28e-2 15/20 (75%) SHMT2;ATIC;MTHFD2;...
Histidine metabolism 1.80 2.85e-2 16/22 (72.73%) ALDH3B1;HAL;ALDH3A2;...
Tyrosine metabolism 1.79 2.72e-2 30/36 (83.33%) ALDH3B1;GOT1;COMT;...
Alanine, aspartate and glutamate metabolism 1.72 4.88e-2 27/37 (72.97%) ASNS;ALDH5A1;ADSL;...
Pentose phosphate pathway 1.72 4.44e-2 25/30 (83.33%) RPIA;RBKS;TKTL1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H