Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTV4L0)

• Drug Name: Myricetin Drug Info
• Synonyms: myricetin; 529-44-2; Cannabiscetin; Myricetol; Myricitin; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one; 3,3',4',5,5',7-Hexahydroxyflavone; 3,5,7,3',4',5'-Hexahydroxyflavone; UNII-76XC01FTOJ; NSC 407290; CCRIS 5838; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one; EINECS 208-463-2; NSC407290; CHEMBL164; NSC-407290; BRN 0332331; 76XC01FTOJ
• Cross-matching ID:
  PubChem CID: 5281672
  ChEBI ID: CHEMBL164
  CAS Number: CAS 529-44-2
  TTD Drug ID: D0T3PW
  VARIDT Drug ID: DR00676

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.19	0.00e+0	34/36 (94.44%)	PRIM2;POLE3;MCM3;...
Homologous recombination	1.85	3.48e-2	35/41 (85.37%)	BRIP1;BARD1;RBBP8;...
Cell cycle	1.83	3.19e-2	110/124 (88.71%)	PLK1;TGFB3;CCNA2;...
Steroid biosynthesis	1.78	4.57e-2	19/20 (95%)	SQLE;MSMO1;LIPA;...
Oocyte meiosis	1.75	4.52e-2	90/129 (69.77%)	CALML3;PLK1;MAD2L1;...
ABC transporters	-1.68	4.64e-2	37/45 (82.22%)	ABCA8;ABCB4;ABCA7;...
Staphylococcus aureus infection	-1.68	4.87e-2	72/95 (75.79%)	PTAFR;C1QA;PLG;...
Riboflavin metabolism	-1.69	4.59e-2	7/8 (87.5%)	ACP5;ACP2;BLVRB
Glycosaminoglycan biosynthesis	-1.71	3.83e-2	40/58 (68.97%)	B4GALT1;B3GAT3;CHPF2;...
Basal cell carcinoma	-1.71	4.06e-2	41/63 (65.08%)	AXIN1;DVL2;FZD10;...
Other glycan degradation	-1.73	3.82e-2	13/18 (72.22%)	ENGASE;HEXA;MAN2B2;...
Phagosome	-1.78	2.44e-2	118/152 (77.63%)	MBL2;FCGR2B;THBS2;...
Complement and coagulation cascades	-1.78	2.71e-2	76/85 (89.41%)	C1QA;PLG;CD59;...
Ovarian steroidogenesis	-1.81	1.94e-2	41/51 (80.39%)	PTGS2;CGA;PRKACB;...
Mineral absorption	-1.82	2.06e-2	48/60 (80%)	MT1HL1;MT1F;ATP1B1;...
Porphyrin and chlorophyll metabolism	-1.86	1.29e-2	23/43 (53.49%)	COX15;UGT2B17;ALAD;...
Retinol metabolism	-1.88	1.33e-2	41/68 (60.29%)	UGT2B4;CYP3A7;DHRS9;...
Lysosome	-1.93	5.54e-3	115/128 (89.84%)	IDUA;AP3S2;HEXA;...
Ferroptosis	-2.06	3.69e-3	36/41 (87.8%)	CP;FTL;GSS;...
Mitophagy	-2.07	5.54e-3	56/68 (82.35%)	BCL2L1;CSNK2A2;BECN1;...
Antigen processing and presentation	-2.15	0.00e+0	60/78 (76.92%)	HSPA1L;TAP2;HLA-DOB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.2uM - 25uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.2uM - 25uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H	Show ▼