Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTVGMZ)

Drug Name
NKP 608 Drug Info
Synonyms AV608)
Cross-matching ID
PubChem CID
9917079
ChEBI ID
CHEMBL1765508
CAS Number
CAS 177707-12-9
TTD Drug ID
D0V7US

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Tyrosine metabolism 2.13 0.00e+0 30/36 (83.33%) MAOA;DCT;TYRP1;...
Steroid biosynthesis 1.95 9.97e-3 19/20 (95%) MSMO1;CYP51A1;SOAT1;...
Pentose phosphate pathway 1.92 1.66e-2 25/30 (83.33%) G6PD;PFKL;TKTL1;...
Tryptophan metabolism 1.91 1.25e-2 35/42 (83.33%) KYNU;MAOA;DHTKD1;...
Pentose and glucuronate interconversions 1.91 9.97e-3 17/34 (50%) AKR1B1;GUSB;AKR1B10;...
Bile secretion 1.89 8.31e-3 68/90 (75.56%) GNAS;EPHX1;CYP3A4;...
Galactose metabolism 1.87 8.55e-3 26/31 (83.87%) PFKL;AKR1B1;MGAM;...
Glycolysis / Gluconeogenesis 1.86 8.73e-3 56/67 (83.58%) PFKL;ENO2;ALDH3A2;...
Ascorbate and aldarate metabolism 1.85 9.97e-3 15/30 (50%) ALDH3A2;GUSB;AKR1A1;...
Fructose and mannose metabolism 1.72 3.49e-2 30/33 (90.91%) PFKL;AKR1B1;AKR1B10;...
Histidine metabolism 1.68 4.71e-2 16/22 (72.73%) MAOA;ALDH3A2;ALDH3B1;...
Viral protein interaction with cytokine and cytokine re... -1.98 4.01e-2 84/100 (84%) CXCL11;TNFRSF1B;CCL18;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H