Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTWS9E)

Drug Name
Apremilast Drug Info
Synonyms Apremilast (USAN); CC-10004; N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
Cross-matching ID
PubChem CID
11561674
ChEBI ID
CHEMBL514800
CAS Number
CAS 608141-41-9
TTD Drug ID
D07ESC
VARIDT Drug ID
DR01264
INTEDE Drug ID
DR0124
ACDINA Drug ID
D00041

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Osteoclast differentiation -1.67 3.64e-2 117/127 (92.13%) JUNB;TRAF6;TNFRSF11A;...
Th1 and Th2 cell differentiation -1.68 3.39e-2 80/92 (86.96%) HLA-DRB1;NOTCH1;JAG2;...
B cell receptor signaling pathway -1.71 2.03e-2 71/81 (87.65%) CD79B;PIK3R1;CD19;...
NOD-like receptor signaling pathway -1.72 2.14e-2 145/181 (80.11%) IFNAR2;BIRC2;GABARAPL2;...
T cell receptor signaling pathway -1.72 2.13e-2 93/104 (89.42%) PAK3;ZAP70;CD247;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.73 1.99e-2 79/89 (88.76%) CSNK2A2;ZAP70;CD247;...
Neutrophil extracellular trap formation -1.76 1.62e-2 101/189 (53.44%) SELPLG;CYBB;FCGR3B;...
Lipid and atherosclerosis -1.79 1.28e-2 190/215 (88.37%) IL18;PTK2;MAP2K3;...
Primary immunodeficiency -1.83 9.67e-3 33/38 (86.84%) TAP1;TAP2;RFXANK;...
Hematopoietic cell lineage -1.84 7.81e-3 90/99 (90.91%) IL6;GP1BA;CSF1;...
Amoebiasis -1.84 8.46e-3 99/102 (97.06%) RAB5A;GNA14;COL4A1;...
Kaposi sarcoma-associated herpesvirus infection -1.85 9.23e-3 172/193 (89.12%) CCND1;PIK3R1;PPP3CC;...
Small cell lung cancer -1.87 6.77e-3 90/92 (97.83%) BAX;LAMB4;LAMB2;...
Bladder cancer -1.89 3.76e-3 40/41 (97.56%) DAPK3;CDH1;CCND1;...
Viral protein interaction with cytokine and cytokine re... -1.92 4.23e-3 84/100 (84%) CCR7;IL6;CCR2;...
Legionellosis -1.96 4.84e-3 51/57 (89.47%) CASP1;ITGB2;NFKBIA;...
Pertussis -1.97 3.76e-3 64/76 (84.21%) TRAF6;NFKB1;RHOA;...
NF-kappa B signaling pathway -1.99 2.26e-3 90/104 (86.54%) PLAU;BCL2;LTBR;...
TNF signaling pathway -2.08 0.00e+0 103/112 (91.96%) MAP3K8;MAP2K3;PIK3R1;...
Rheumatoid arthritis -2.10 0.00e+0 78/93 (83.87%) ATP6V1F;HLA-DRB1;IL18;...
Epithelial cell signaling in Helicobacter pylori infect... -2.13 0.00e+0 62/70 (88.57%) MAPK13;PTPRZ1;MAPK9;...
IL-17 signaling pathway -2.61 0.00e+0 84/94 (89.36%) CXCL6;MAPK13;ANAPC5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H