Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTYCJ6)

Drug Name
BW B70C Drug Info
Synonyms
BW B70C; BWB70C; BW-B 70C; 134470-38-5; BW-B70C; CHEMBL86676; CHEBI:75307; (E)-N-(3-(3-(4-Fluorophenoxy)phenyl)-1-(R,S)-methylprop-2-enyl)-N-hydroxyurea; 70C; N-[3-[3-4(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea; N-(3-(3-(4-Fluorophenoxy)phenyl)-1-methyl-2-propenyl)-N-hydroxyurea; Urea, N-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-N-hydroxy-; C17H17FN2O3; SR-01000075717; (e)-N-{3-[3-(4-fluorophenoxy)phenyl]-1-(r,s)-methylprop-2-enyl}-N-hydroxyurea; Lopac0_000202; BSPBio_001512; SCHEMBL2681955
Cross-matching ID
PubChem CID
5353454
ChEBI ID
CHEMBL75307
CAS Number
CAS 134470-38-5
TTD Drug ID
D0HJ1Y

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.17 0.00e+0 56/67 (83.58%) FBP1;ENO2;ADH1C;...
Aldosterone-regulated sodium reabsorption 2.15 0.00e+0 34/37 (91.89%) HSD11B2;SCNN1A;ATP1A1;...
Mineral absorption 2.15 0.00e+0 48/60 (80%) FTH1;ATP2B1;ATP1A1;...
Proximal tubule bicarbonate reclamation 2.07 3.58e-3 21/23 (91.3%) CA2;SLC4A4;ATP1A1;...
Pancreatic secretion 2.06 2.86e-3 87/102 (85.29%) CA2;CLCA4;SLC4A4;...
Other glycan degradation 1.99 4.77e-3 13/18 (72.22%) HEXB;AGA;MAN2B2;...
Metabolism of xenobiotics by cytochrome P450 1.96 4.09e-3 49/77 (63.64%) CYP1B1;AKR1C1;ADH1C;...
Carbohydrate digestion and absorption 1.92 5.37e-3 37/47 (78.72%) PLCB1;ATP1A1;PIK3CA;...
Steroid hormone biosynthesis 1.91 4.77e-3 43/61 (70.49%) AKR1C3;CYP1B1;AKR1C2;...
Nitrogen metabolism 1.89 5.72e-3 16/17 (94.12%) CA12;CA2;GLUD1;...
Endocrine and other factor-regulated calcium reabsorpti... 1.88 5.20e-3 49/53 (92.45%) PLCB1;ATP2B1;ATP1A1;...
Ferroptosis 1.86 7.15e-3 36/41 (87.8%) SLC39A8;FTH1;HMOX1;...
VEGF signaling pathway 1.85 9.91e-3 50/59 (84.75%) PTGS2;VEGFA;PIK3CA;...
Pentose phosphate pathway 1.83 1.23e-2 25/30 (83.33%) FBP1;PRPS2;PFKP;...
Galactose metabolism 1.80 1.72e-2 26/31 (83.87%) AKR1B10;PFKP;PFKL;...
Bile secretion 1.77 2.15e-2 68/90 (75.56%) ABCC3;CA2;SLC4A4;...
Fructose and mannose metabolism 1.77 2.10e-2 30/33 (90.91%) AKR1B10;FBP1;PFKP;...
Arachidonic acid metabolism 1.76 2.46e-2 48/61 (78.69%) GPX2;PTGS2;AKR1C3;...
Gastric acid secretion 1.76 2.33e-2 63/76 (82.89%) CA2;PLCB1;ITPR1;...
Tryptophan metabolism 1.75 2.36e-2 35/42 (83.33%) MAOA;CYP1B1;AOC1;...
beta-Alanine metabolism 1.75 2.45e-2 25/30 (83.33%) ACOX1;ALDH6A1;ALDH2;...
Pentose and glucuronate interconversions 1.74 2.54e-2 17/34 (50%) AKR1B10;UGT2B15;UGT2B17;...
MicroRNAs in cancer 1.73 2.61e-2 146/310 (47.1%) PTGS2;CYP1B1;DDIT4;...
HIF-1 signaling pathway 1.71 2.98e-2 105/109 (96.33%) IL6;ENO2;VEGFA;...
Rheumatoid arthritis 1.68 3.78e-2 78/93 (83.87%) IL6;VEGFA;CXCL5;...
Type II diabetes mellitus 1.68 3.74e-2 42/46 (91.3%) PIK3CA;HK2;PKM;...
Intestinal immune network for IgA production 1.63 4.10e-2 38/48 (79.17%) IL6;CD40;TNFSF13;...
Glutamatergic synapse 1.62 4.15e-2 97/114 (85.09%) SLC1A1;PLCB1;ITPR1;...
Amoebiasis 1.62 4.08e-2 99/102 (97.06%) IL6;PLCB1;LAMB1;...
Viral protein interaction with cytokine and cytokine re... 1.62 4.15e-2 84/100 (84%) IL6;ACKR3;CXCL5;...
Ribosome biogenesis in eukaryotes -1.82 4.31e-3 52/108 (48.15%) NXT2;GNL2;MDN1;...
RNA polymerase -1.85 1.44e-3 23/31 (74.19%) POLR1D;POLR2C;POLR3F;...
Ribosome -1.88 2.15e-3 113/158 (71.52%) RPL4;RPS12;RPL32;...
Proteasome -1.93 4.31e-3 44/46 (95.65%) PSMA1;PSMD11;PSME3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H