Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMTZYQ3)

• Drug Name: LP99 Drug Info
• Synonyms: compound 60 [PMID: 25864491]
• Cross-matching ID:
  PubChem CID: 91827372
  ChEBI ID: CHEMBL3753082
  TTD Drug ID: D08LXU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Neutrophil extracellular trap formation	1.94	1.09e-2	101/189 (53.44%)	HDAC9;PLCB1;FGG;...
TNF signaling pathway	1.83	4.36e-2	103/112 (91.96%)	DNM1L;JAG1;BIRC3;...
Type I diabetes mellitus	-1.84	3.20e-2	38/43 (88.37%)	INS;TNF;HLA-C;...
Fat digestion and absorption	-1.84	3.97e-2	35/43 (81.4%)	LIPF;PNLIP;AGPAT2;...
Protein export	-1.92	1.83e-2	17/23 (73.91%)	SEC61G;SRPRB;SRP14;...
PPAR signaling pathway	-2.23	0.00e+0	66/74 (89.19%)	ACAA1;HMGCS1;APOA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲