Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU10FE)

• Drug Name: THZ1 Drug Info
• Synonyms: HY-80013
• Cross-matching ID:
  PubChem CID: 73602827
  ChEBI ID: CHEMBL3603847
  TTD Drug ID: D0LO5B

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.04	0.00e+0	76/85 (89.41%)	SERPINB2;SERPINA1;C3;...
PPAR signaling pathway	2.03	0.00e+0	66/74 (89.19%)	FABP4;PCK1;SORBS1;...
Tyrosine metabolism	1.98	0.00e+0	30/36 (83.33%)	ADH1B;AOX1;AOC3;...
Cholesterol metabolism	1.92	1.40e-2	44/50 (88%)	APOB;PLTP;APOH;...
Biosynthesis of unsaturated fatty acids	1.89	1.40e-2	21/27 (77.78%)	SCD;ELOVL5;ACAA1;...
Type I diabetes mellitus	1.88	1.17e-2	38/43 (88.37%)	GAD1;IFNG;IL1A;...
Retinol metabolism	1.86	1.60e-2	41/68 (60.29%)	ADH1B;AOX1;ALDH1A1;...
Glyoxylate and dicarboxylate metabolism	1.85	1.40e-2	23/30 (76.67%)	GLDC;ACAT1;GLUL;...
Vitamin digestion and absorption	1.80	2.49e-2	17/24 (70.83%)	APOB;SLC5A6;APOA1;...
Morphine addiction	1.78	2.66e-2	80/91 (87.91%)	GNAS;PDE1A;PDE8B;...
Pentose and glucuronate interconversions	1.78	2.80e-2	17/34 (50%)	DCXR;AKR1B10;UGP2;...
Graft-versus-host disease	1.74	4.79e-2	32/42 (76.19%)	IFNG;IL1A;HLA-E;...
Ribosome biogenesis in eukaryotes	-1.90	1.89e-2	52/108 (48.15%)	EFL1;HEATR1;GAR1;...
Spliceosome	-1.91	3.78e-2	101/150 (67.33%)	SNRNP200;SNRNP40;SNRPC;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲