Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU3IET)

• Drug Name: Thiethylperazine Drug Info
• Synonyms: ETHYLTHIOPERAZINE; Theithylperazine; Thiethylperazinum; Thiethylpipezazine; Thioethylperazine; Tietilperazina; Torecan; Tietilperazina [DCIT]; Thiethylperazinum [INN-Latin]; Torecan (TN); Thiethylperazine (USAN/INN); Thiethylperazine [USAN:INN:BAN]; Norzine (*Dimaleate*); GS-95 (*Dimaleate*)
• Therapeutic Class: Antiemetics
• Cross-matching ID:
  PubChem CID: 5440
  ChEBI ID: CHEMBL9544
  CAS Number: CAS 1420-55-9
  TTD Drug ID: D0Y0ER

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Morphine addiction	-1.72	3.98e-2	80/91 (87.91%)	KCNJ5;GABRR2;PDE11A;...
Neuroactive ligand-receptor interaction	-1.75	2.79e-2	294/341 (86.22%)	FSHB;ADRA1D;P2RX4;...
Pancreatic secretion	-1.77	2.91e-2	87/102 (85.29%)	CHRM3;RAP1A;PNLIPRP2;...
Nitrogen metabolism	-1.79	3.49e-2	16/17 (94.12%)	CA3;CPS1;CA14;...
Amphetamine addiction	-1.82	2.57e-2	57/69 (82.61%)	GRIA1;ATF2;PRKCB;...
Nicotine addiction	-1.86	2.74e-2	32/40 (80%)	GRIN2B;GABRR2;GABRA4;...
IL-17 signaling pathway	-1.92	1.03e-2	84/94 (89.36%)	MUC5B;JUN;CEBPB;...
Mineral absorption	-2.53	0.00e+0	48/60 (80%)	HMOX1;ATP1B2;ATP2B1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼