Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU4T9Y)

Drug Name
Dimesna Drug Info
Synonyms Tavocept (TN)
Cross-matching ID
PubChem CID
65625
CAS Number
CAS 16208-51-8
TTD Drug ID
D05KZM
VARIDT Drug ID
DR00091

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Thermogenesis -1.71 3.79e-2 173/232 (74.57%) MAPK13;MAPK11;RPS6KA2;...
Ribosome -1.76 2.58e-2 113/158 (71.52%) RPS24;RPL30;RPS15;...
Huntington disease -1.81 1.36e-2 233/306 (76.14%) CREB3;ACTR10;GRIA3;...
Propanoate metabolism -1.87 1.01e-2 30/34 (88.24%) MLYCD;ACADS;HADHA;...
Regulation of lipolysis in adipocytes -1.87 9.95e-3 52/55 (94.55%) MGLL;ADCY3;ABHD5;...
Non-alcoholic fatty liver disease -1.89 8.12e-3 126/155 (81.29%) MAPK13;MAPK11;NDUFS1;...
Glyoxylate and dicarboxylate metabolism -1.89 9.47e-3 23/30 (76.67%) MDH2;SHMT1;MDH1;...
Valine, leucine and isoleucine degradation -1.90 9.09e-3 42/48 (87.5%) HMGCL;ACADS;ACAD8;...
Diabetic cardiomyopathy -1.91 8.52e-3 162/203 (79.8%) COX7C;RAC2;COX7A1;...
Parkinson disease -1.99 3.79e-3 176/249 (70.68%) RPS27A;SNCA;MFN1;...
Citrate cycle (TCA cycle) -2.18 0.00e+0 30/30 (100%) CS;FH;IDH3G;...
Oxidative phosphorylation -2.60 0.00e+0 93/133 (69.92%) TCIRG1;COX7C;COX7A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H