Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU6OB4)

Drug Name
Costunolide Drug Info
Synonyms
Costunolide; Costunolid; Costus lactone; Costunlide; AC1NSPGS; HRYLQFBHBWLLLL-GYIATTAWSA-N; Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, [3aS-(3aR*,6E,10E,11aS*)]-; BRD-A49888826-001-01-8; (6E,10E)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one; (E,E)-6-.alpha.-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid .gamma.-lactone; Germacra-1(10),4,11(13)-trien-12-oic acid, 6.alpha.-hydroxy-, .gamma.-lactone, (E,E)-
Cross-matching ID
PubChem CID
5281437
ChEBI ID
CHEMBL86416
CAS Number
CAS 553-21-9
TTD Drug ID
D07KNG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ABC transporters 2.03 0.00e+0 37/45 (82.22%) ABCG2;ABCC3;ABCC2;...
Phototransduction 1.99 0.00e+0 21/29 (72.41%) CALML3;CALML5
Ferroptosis 1.99 0.00e+0 36/41 (87.8%) HMOX1;GCLM;GCLC;...
Glutathione metabolism 1.98 0.00e+0 43/57 (75.44%) GCLM;G6PD;GSTA4;...
Sphingolipid metabolism 1.92 9.87e-3 32/49 (65.31%) GLA;PLPP2;DEGS1;...
Fluid shear stress and atherosclerosis 1.87 1.64e-2 123/139 (88.49%) HMOX1;TXN;CTSL;...
Viral protein interaction with cytokine and cytokine re... 1.83 2.11e-2 84/100 (84%) TNFRSF1A;CX3CR1;CXCL5;...
Various types of N-glycan biosynthesis 1.79 2.77e-2 26/39 (66.67%) MGAT4B;FUT8;MAN1A1;...
Porphyrin and chlorophyll metabolism 1.78 2.60e-2 23/43 (53.49%) HMOX1;ALAS1;BLVRB;...
Lysosome 1.72 4.81e-2 115/128 (89.84%) CTSL;GLA;ACP2;...
HIF-1 signaling pathway 1.69 4.93e-2 105/109 (96.33%) HMOX1;IGF1;CDKN1A;...
Galactose metabolism 1.69 4.86e-2 26/31 (83.87%) AKR1B10;GLA;PFKP;...
Amino sugar and nucleotide sugar metabolism 1.69 4.79e-2 38/48 (79.17%) AMDHD2;UGDH;CYB5R2;...
Butanoate metabolism -1.74 4.57e-2 23/28 (82.14%) HMGCS1;ABAT;ALDH5A1;...
Ribosome -2.22 0.00e+0 113/158 (71.52%) RPL37;RPS10;RPL38;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 3.33uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H