Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU73F0)

Drug Name
Bifemelane Drug Info
Synonyms Alnert; Celeport; E-0687; MCI-2016; SON-216
Cross-matching ID
PubChem CID
2377
ChEBI ID
CHEMBL92338
CAS Number
CAS 90293-01-9
TTD Drug ID
D02CGY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.14 0.00e+0 19/20 (95%) NSDHL;DHCR24;SOAT1;...
IL-17 signaling pathway -1.74 4.60e-2 84/94 (89.36%) MAPK10;NFKB1;TNF;...
Non-alcoholic fatty liver disease -1.84 1.79e-2 126/155 (81.29%) NDUFA9;NDUFA1;EIF2S1;...
Parkinson disease -2.00 4.77e-3 176/249 (70.68%) NFE2L2;SLC18A2;NDUFS7;...
Metabolism of xenobiotics by cytochrome P450 -2.01 5.96e-3 49/77 (63.64%) GSTM1;CBR1;MGST3;...
Drug metabolism -2.02 0.00e+0 78/151 (51.66%) NME4;DPYS;MGST3;...
Retinol metabolism -2.10 0.00e+0 41/68 (60.29%) RDH16;CYP3A5;ADH5;...
Oxidative phosphorylation -2.15 0.00e+0 93/133 (69.92%) NDUFS7;NDUFB11;ATP5MC1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H