Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU7YEL)

• Drug Name: Sufentanil Drug Info
• Synonyms: Chronogesic; Sufentanilum; Sufentanyl; Sulfentanil; Sulfentanyl; R 30730; R-30730; Sufenta (TN); Sufentanilum [INN-Latin]; Sufentil (TN); Sufentanil (USAN/INN); Sufentanil [USAN:BAN:INN]; N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide; N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide; N-{4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-phenylpropanamide; N-{4-[(methyloxy)methyl]-1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-phenylpropanamide; N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide
• Therapeutic Class: Anesthetics
• Cross-matching ID:
  PubChem CID: 41693
  ChEBI ID: CHEMBL658
  CAS Number: CAS 56030-54-7
  TTD Drug ID: D0D8DD
  VARIDT Drug ID: DR00602
  INTEDE Drug ID: DR1508

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Citrate cycle (TCA cycle)	2.08	0.00e+0	30/30 (100%)	SUCLG2;DLD;IDH1;...
Phosphatidylinositol signaling system	1.89	2.48e-2	82/97 (84.54%)	PLCE1;ITPR1;DGKD;...
Fatty acid elongation	1.87	1.66e-2	19/27 (70.37%)	HACD2;ELOVL5;ECHS1;...
Mismatch repair	1.85	1.55e-2	22/23 (95.65%)	POLD4;MSH2;RFC2;...
Cholesterol metabolism	-1.84	4.44e-2	44/50 (88%)	APOH;APOE;ABCB11;...
Coronavirus disease	-1.89	3.33e-2	215/232 (92.67%)	RPS6;RPL41;RPSA;...
Ribosome	-2.54	0.00e+0	113/158 (71.52%)	RPS23;RPS27;RPS7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼