Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU8KGB)

• Drug Name: SBB007833 Drug Info
• Synonyms: NSC 10120; NSC 105303; NSC 170724
• Cross-matching ID:
  PubChem CID: 672296
  ChEBI ID: CHEMBL596380
  CAS Number: CAS 22568-48-5
  TTD Drug ID: D03YUW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cardiac muscle contraction	2.01	7.99e-3	64/87 (73.56%)	TNNC1;MYL2;TPM3;...
Th1 and Th2 cell differentiation	-1.69	4.45e-2	80/92 (86.96%)	IKBKB;IFNGR1;NOTCH1;...
Alanine, aspartate and glutamate metabolism	-1.69	4.82e-2	27/37 (72.97%)	PPAT;ASPA;ALDH4A1;...
Neomycin, kanamycin and gentamicin biosynthesis	-1.70	4.72e-2	5/5 (100%)	HK2
Hedgehog signaling pathway	-1.73	4.01e-2	43/56 (76.79%)	SPOP;GLI3;GAS1;...
Viral protein interaction with cytokine and cytokine re...	-1.73	4.46e-2	84/100 (84%)	IL6;CCL23;LTA;...
Proximal tubule bicarbonate reclamation	-1.75	4.13e-2	21/23 (91.3%)	AQP1;SLC25A10;FXYD2;...
Autoimmune thyroid disease	-1.80	3.20e-2	46/53 (86.79%)	HLA-DQB1;HLA-DPB1;HLA-DOB;...
Systemic lupus erythematosus	-1.83	2.75e-2	45/135 (33.33%)	ACTN4;ACTN1;ELANE;...
Intestinal immune network for IgA production	-1.83	3.31e-2	38/48 (79.17%)	CD40LG;IL6;CD86;...
Type I diabetes mellitus	-1.93	1.18e-2	38/43 (88.37%)	HLA-DQB1;HLA-DPB1;HLA-DOB;...
Allograft rejection	-1.95	1.57e-2	32/38 (84.21%)	HLA-DQB1;HLA-DPB1;HLA-DOB;...
Staphylococcus aureus infection	-1.96	1.18e-2	72/95 (75.79%)	CAMP;C3AR1;SELP;...
Asthma	-2.21	0.00e+0	25/31 (80.65%)	CCL11;HLA-DQB1;RNASE3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲