Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU8V4S)

Drug Name
Moxifloxacin Drug Info
Synonyms
Avelox; MFX; MXF; MXFX; Vigamox; Avalox (TN); Avelon (TN); Avelox (TN); Moxifloxacin [INN:BAN]; Vigamox (TN); Avelox I.V.; Actira (*Hydrochloride*); Avelox (*Hydrochloride*); (1'S,6'S)-1-Cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid; 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
Therapeutic ClassAntibiotics
Cross-matching ID
PubChem CID
152946
ChEBI ID
CHEMBL32
CAS Number
CAS 151096-09-2
TTD Drug ID
D0ZV0Z
VARIDT Drug ID
DR00800
ACDINA Drug ID
D00448

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.66 0.00e+0 44/46 (95.65%) PSMD14;PSMA1;PSMD1;...
Ribosome biogenesis in eukaryotes 2.54 0.00e+0 52/108 (48.15%) NOP56;RPP40;NXT1;...
Spliceosome 2.15 0.00e+0 101/150 (67.33%) LSM5;HSPA8;HSPA1A;...
DNA replication 2.08 1.32e-3 34/36 (94.44%) PCNA;RFC3;MCM2;...
Aminoacyl-tRNA biosynthesis 2.05 2.11e-3 15/66 (22.73%) LARS2;QRSL1;FARS2;...
RNA polymerase 2.04 1.76e-3 23/31 (74.19%) POLR3K;POLR2G;POLR3F;...
Base excision repair 1.83 1.28e-2 29/33 (87.88%) PCNA;FEN1;POLD3;...
Spinocerebellar ataxia 1.75 2.51e-2 128/143 (89.51%) NOP56;PSMD14;PSMA1;...
Pyrimidine metabolism 1.74 2.35e-2 40/56 (71.43%) ENPP1;NME1;UMPS;...
Mismatch repair 1.73 2.43e-2 22/23 (95.65%) PCNA;RFC3;POLD3;...
Ribosome 1.72 2.40e-2 113/158 (71.52%) RPS4Y1;MRPS2;MRPL3;...
RNA transport 1.69 2.91e-2 128/186 (68.82%) RPP40;NXT1;RAN;...
Amyotrophic lateral sclerosis 1.66 3.37e-2 267/364 (73.35%) BAD;NEFH;PSMD14;...
Folate biosynthesis 1.66 3.17e-2 23/26 (88.46%) PTS;AKR1B10;MOCS2;...
Cell cycle 1.62 4.09e-2 110/124 (88.71%) PCNA;CDC45;CDC20;...
RNA degradation 1.61 4.06e-2 53/79 (67.09%) LSM5;EXOSC4;HSPD1;...
Prion disease 1.61 3.95e-2 209/273 (76.56%) BAD;HSPA8;HSPA1A;...
Fanconi anemia pathway 1.59 4.08e-2 36/54 (66.67%) CENPX;BRCA1;FANCG;...
Propanoate metabolism 1.56 4.98e-2 30/34 (88.24%) LDHA;HIBCH;SUCLA2;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.56 4.78e-2 9/11 (81.82%) NQO1;COQ2;COQ3;...
Rap1 signaling pathway -1.59 4.13e-2 184/210 (87.62%) SRC;FGF7;PRKD2;...
Relaxin signaling pathway -1.60 4.11e-2 114/129 (88.37%) PRKACA;PLCB2;GNG3;...
mTOR signaling pathway -1.64 4.14e-2 114/154 (74.03%) PIK3CB;AKT1;SLC3A2;...
Lysosome -1.65 3.89e-2 115/128 (89.84%) IDUA;ASAH1;ABCA2;...
Adipocytokine signaling pathway -1.67 3.47e-2 64/69 (92.75%) ACSL6;PRKAB1;STAT3;...
Adherens junction -1.67 3.54e-2 63/71 (88.73%) TJP1;PTPN6;WAS;...
Terpenoid backbone biosynthesis -1.68 3.24e-2 18/22 (81.82%) ICMT;FNTA;HMGCS2;...
T cell receptor signaling pathway -1.68 3.37e-2 93/104 (89.42%) NCK2;CD3E;PAK4;...
Kaposi sarcoma-associated herpesvirus infection -1.68 3.45e-2 172/193 (89.12%) SRC;CASP8;RAC1;...
Breast cancer -1.69 3.35e-2 119/147 (80.95%) TCF7L2;TCF7;FGF20;...
Mucin type O-glycan biosynthesis -1.69 3.18e-2 20/36 (55.56%) GALNT1;GALNT6;GALNT8;...
Non-small cell lung cancer -1.69 3.33e-2 70/72 (97.22%) KIF5C;PIK3CB;AKT1;...
Endometrial cancer -1.70 3.43e-2 56/58 (96.55%) CTNNA1;TCF7L2;TCF7;...
Pancreatic cancer -1.70 3.61e-2 75/76 (98.68%) RELA;PIK3CB;AKT1;...
Shigellosis -1.70 3.73e-2 180/246 (73.17%) C3;PLCB2;CASP1;...
Mitophagy -1.71 3.78e-2 56/68 (82.35%) RELA;MAPK9;BCL2L13;...
Yersinia infection -1.72 3.75e-2 120/137 (87.59%) ARHGEF12;CD8B;ARHGEF1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.73 4.00e-2 62/70 (88.57%) SRC;ATP6V0C;RAC1;...
Neutrophil extracellular trap formation -1.76 3.81e-2 101/189 (53.44%) TLR7;TLR8;C3;...
Insulin resistance -1.77 3.51e-2 96/108 (88.89%) SREBF1;MLXIPL;OGA;...
Amoebiasis -1.82 2.71e-2 99/102 (97.06%) PRKACA;GNAL;GNAQ;...
NF-kappa B signaling pathway -1.83 2.86e-2 90/104 (86.54%) CSNK2A2;BLNK;LY96;...
Leukocyte transendothelial migration -1.83 3.04e-2 90/114 (78.95%) CTNNA1;RAC1;CLDN4;...
Osteoclast differentiation -1.86 2.65e-2 117/127 (92.13%) CTSK;RAC1;IL1B;...
Chagas disease -1.87 2.86e-2 93/102 (91.18%) IL2;C3;GNAL;...
Carbohydrate digestion and absorption -1.87 3.43e-2 37/47 (78.72%) CACNA1D;PIK3CB;SLC37A4;...
Rheumatoid arthritis -1.88 3.93e-2 78/93 (83.87%) CTSK;ATP6V0C;ATP6V0A1;...
Steroid biosynthesis -1.96 4.76e-3 19/20 (95%) NSDHL;DHCR7;HSD17B7;...
IL-17 signaling pathway -2.15 0.00e+0 84/94 (89.36%) MUC5B;JUND;IKBKE;...
TNF signaling pathway -2.28 0.00e+0 103/112 (91.96%) MAP3K8;RELA;MAP2K6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 1.11uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 1.11uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H