Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU9D2F)

Drug Name
Gabexate Drug Info
Synonyms
gabexate; Gabexate [INN]; 39492-01-8; Gabexatum [INN-Latin]; Gabexato [INN-Spanish]; UNII-4V7M9137X9; CHEMBL87563; C16H23N3O4; Gabexate (INN); 4V7M9137X9; Ethyl p-hydroxybenzoate 6-guanidinohexanoate; ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate; Gabexatum; Gabexato; Benzoic acid, 4-((6-((aminoiminomethyl)amino)-1-oxohexyl)oxy)-, ethyl ester; p-carbethoxyphenyl e-guanidinocaproate; AC1L1FYH; Prestwick3_001008; Prestwick2_001008; Prestwick0_001008; Prestwick1_001008; BSPBio_001135; SCHEMBL446024; SPBio_003016; GTPL7863
Cross-matching ID
PubChem CID
3447
ChEBI ID
CHEMBL87563
CAS Number
CAS 39492-01-8
TTD Drug ID
D05PHH
VARIDT Drug ID
DR00837

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Drug metabolism 2.05 0.00e+0 78/151 (51.66%) RRM2;CYP2C9;TYMP;...
Pyrimidine metabolism 1.92 7.50e-3 40/56 (71.43%) DCK;TYMS;RRM2;...
Metabolism of xenobiotics by cytochrome P450 1.82 3.50e-2 49/77 (63.64%) CYP2C9;CYP1A2;CYP2E1;...
Mineral absorption 1.81 2.63e-2 48/60 (80%) MT1E;MT1F;SLC11A2;...
Rheumatoid arthritis -1.99 4.27e-3 78/93 (83.87%) CTSK;IL23A;TNFRSF11A;...
Vibrio cholerae infection -2.00 6.40e-3 44/50 (88%) SEC61A1;ATP6V1A;ATP6V0E2;...
Basal cell carcinoma -2.01 1.28e-2 41/63 (65.08%) FZD6;TP53;WNT7A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H