Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMU9VDS)

Drug Name
Mibefradil Drug Info
Synonyms
Mibefradil (Cytostatic Checkpoint Therapy, ovarian cancer); Mibefradil (Cytostatic Checkpoint Therapy, ovarian cancer), Tau Therapeutics; Calcium T-channel inhibitor (Cytostatic Checkpoint Therapy, ovarian cancer), Tau Therapeutics
Cross-matching ID
PubChem CID
60663
ChEBI ID
CHEMBL6920
CAS Number
CAS 116644-53-2
TTD Drug ID
D0W8XT
VARIDT Drug ID
DR00781
INTEDE Drug ID
DR1082

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.67 0.00e+0 19/20 (95%) MSMO1;NSDHL;SQLE;...
Terpenoid backbone biosynthesis 2.18 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;HMGCR;...
Steroid hormone biosynthesis 2.10 0.00e+0 43/61 (70.49%) AKR1C2;AKR1C3;AKR1C1;...
Metabolism of xenobiotics by cytochrome P450 1.90 1.15e-2 49/77 (63.64%) AKR1C1;ALDH3A1;GSTA1;...
Synthesis and degradation of ketone bodies 1.88 9.22e-3 9/10 (90%) HMGCS1;ACAT2;BDH2;...
Lysosome 1.80 3.26e-2 115/128 (89.84%) NEU1;NPC2;CTSH;...
Butanoate metabolism 1.78 3.13e-2 23/28 (82.14%) HMGCS1;ACAT2;EHHADH;...
Glutathione metabolism 1.71 4.95e-2 43/57 (75.44%) GPX2;IDH1;G6PD;...
Autophagy 1.70 4.92e-2 113/169 (66.86%) DDIT4;SQSTM1;IRS1;...
Renin-angiotensin system 1.69 4.61e-2 20/23 (86.96%) ACE2;CPA3;AGTR1;...
Phenylalanine metabolism 1.68 4.96e-2 14/17 (82.35%) ALDH3A1;GLYAT;PAH;...
Mitophagy 1.68 4.69e-2 56/68 (82.35%) SQSTM1;KRAS;OPTN;...
Pentose and glucuronate interconversions 1.67 4.76e-2 17/34 (50%) SORD;DCXR;UGDH;...
Ribosome biogenesis in eukaryotes -1.89 2.07e-2 52/108 (48.15%) MPHOSPH10;RAN;TCOF1;...
DNA replication -2.02 0.00e+0 34/36 (94.44%) SSBP1;PRIM2;POLA1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H