Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUDIR8)

• Drug Name: Fludrocortisone Drug Info
• Synonyms: fludrocortisone; Fluorocortisone; Fluorocortisol; Fluohydrisone; Florinef; Fluohydrocortisone; Astonin-H; Fludrocortone; Alflorone; Fludronef; Fludrone; Fluodrocortisone; 127-31-1; F-Cortef; 9alpha-Fluorocortisol; Fludrocortisona; Fludrocortisonum; F-COL; 9-Fluorocortisol; 9 alpha FF; 9-Fluorohydrocortisone; Cortisol, 9-fluoro-; StC 1400; 9alpha-Fludrocortisone; 9-AFH; 9-alpha-Fluorocortisol; 9-alpha-Fludrocortisone; Fludrocortisonum [INN-Latin]; Fludrocortisona [INN-Spanish]; 9-AF; Alflorone; Astonin; FCOL; Astonin H; Astonin Merck; Merck Brand of Fludrocortisone; U 5963; ZK5; F-Cortef;Florinef (TN); Fludrocortisone (INN); Fludrocortisone [INN:BAN]; Merck, Astonin; Astonin-H (TN); Hydrocortisone-9alpha-fluoro; Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-(8CI); (11beta)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione; (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; 9 Fluoro 17 Hydroxycortisone; 9 Fluorocortisol; 9 Fluorohydrocortisone; 9 alpha Fludrohydrocortisone; 9 alpha Fluoro 17 Hydroxycorticosterone; 9 alpha Fluorohydrocortisone; 9 alpha-Fludrocortisone; 9 alpha-Fluoro-17-Hydroxycorticosterone; 9 alpha-Fluorocortisol; 9 alpha-Fluorohydrocortisone; 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9-Fluoro-17-Hydroxycortisone; 9-alpha-Fluoro-17-hydroxycorticosterone; 9-alpha-Fluorohydrocortisone; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione; 9alpha-Fluoro-17-hydroxycorticosterone; 9alpha-Fluorohydrocortisone; 9alpha-Fluoro-hydrocortisone
• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 31378
  ChEBI ID: CHEMBL50885
  CAS Number: CAS 127-31-1
  TTD Drug ID: D0R7JT
  INTEDE Drug ID: DR0705
  ACDINA Drug ID: D00282

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
IL-17 signaling pathway	2.17	0.00e+0	84/94 (89.36%)	CXCL8;S100A8;S100A9;...
Protein export	1.96	1.43e-2	17/23 (73.91%)	SEC61G;SPCS1;SEC63;...
Hematopoietic cell lineage	-1.74	4.82e-2	90/99 (90.91%)	IL7;GP1BB;IL1R2;...
Arrhythmogenic right ventricular cardiomyopathy	-1.75	4.65e-2	70/77 (90.91%)	TCF7L2;ITGB4;ITGB5;...
Proteoglycans in cancer	-1.84	2.36e-2	172/205 (83.9%)	DROSHA;HSPG2;AKT3;...
Primary immunodeficiency	-1.88	1.55e-2	33/38 (86.84%)	RFX5;PTPRC;ZAP70;...
ECM-receptor interaction	-1.91	1.24e-2	80/88 (90.91%)	CD44;COL4A3;ITGA2B;...
Hypertrophic cardiomyopathy	-1.91	1.55e-2	81/90 (90%)	ITGB4;ITGB5;DAG1;...
Focal adhesion	-1.94	6.88e-3	180/201 (89.55%)	COL4A3;ITGA2B;PXN;...
Dilated cardiomyopathy	-1.95	1.03e-2	86/96 (89.58%)	RYR2;ADCY2;ITGA2B;...
Mineral absorption	-2.48	0.00e+0	48/60 (80%)	TRPV6;VDR;STEAP1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Hide ▲