Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUDJZM)

• Drug Name: Dextromethorphan Drug Info
• Synonyms: Albutussin; Canfodion; Cosylan; Demorphine; Destrometerfano; Dextromethorfan; Dextromethorphane; Dextromethorphanum; Dextrometorfano; Dextrometorphan; Dextromorphan; Dexyromethorphan; Dormetan; Levomethorphan; Levomethorphane; Levomethorphanum; Levometorfano; Methorphan; RACEMETHORPHAN; Trocal; Balminil DM; Balminil DM Children; Benylin Adult Formula Cough Suppressant; Benylin DM for Children; Benylin Pediatric Cough Suppressant; Delsym Cough Formula; Demorphan hydrobromide; Destrometerfano [DCIT]; Dextromethorfan [Czech]; Dextromethorphan Bromhydrate; Hold DM; Koffex DM; Novahistex DM; Novahistine DM; Pertussin DM Extra Strength; Robitussin Maximum Strength Cough Suppressant; Robitussin Pediatric; Robitussin Pediatric Cough Suppressant; Triaminic DM Long Lasting for Children; BA 2666; Benylin DM 12 Hour; Benylin DM for Children 12 Hour; Sucrets 4 Hour Cough Suppressant; Vicks 44 Cough Relief; Calmylin #1; Cough-X; Creo-Terpin; D-Methorphan; Delta-Methorphan; Dextromethorphan (USP); Dextromethorphane [INN-French]; Dextromethorphanum [INN-Latin]; Dextrometorfano [INN-Spanish]; Diabe-Tuss DM Syrup; Hihustan M.; L-Methorphan; Levomethorphane [INN-French]; Levomethorphanum [INN-Latin]; Levometorfano [INN-Spanish]; Neurodex (TN); Pertussin CS Children's Strength; Romilar (TN); Dextromethorphan [USP:INN:BAN]; Levomethorphan [BAN:DCF:INN]; Levomethorphan [INN:BAN:DCF]; Morphinan, 3-methoxy-17-methyl-, (9-alpha,13-alpha,14-alpha)-(9CI); Cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4alpha-iminoethanophenanthren; (+)-3-Methoxy-17-methylmorphinan; (-)-3-Methoxy-N-methylmorphinan; (9alpha,13alpha,14alpha)-17-methyl-3-(methyloxy)morphinan; 3-Methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan; 3-Methoxy-17-methylmorphinan; 3-Methoxy-N-methylmorphinon; 9alpha,13alpha,14alpha-Morphinan, 3-methoxy-17-methyl-(8CI)
• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 5360696
  ChEBI ID: CHEMBL52440
  CAS Number: CAS 125-71-3
  TTD Drug ID: D09OBB
  VARIDT Drug ID: DR00891
  INTEDE Drug ID: DR0476
  ACDINA Drug ID: D00177

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	1.87	0.00e+0	19/20 (95%)	SC5D;SQLE;LSS;...
Protein export	1.85	0.00e+0	17/23 (73.91%)	SEC61A1;OXA1L;SEC61B;...
Phenylalanine metabolism	-1.64	4.51e-2	14/17 (82.35%)	MAOB;MAOA;ALDH3A1
Fat digestion and absorption	-1.65	4.04e-2	35/43 (81.4%)	MTTP;APOB;CD36;...
Nitrogen metabolism	-1.66	3.71e-2	16/17 (94.12%)	CA14;GLUD2;GLUD1;...
Arginine and proline metabolism	-1.70	2.89e-2	39/50 (78%)	ARG1;ALDH4A1;GATM;...
Bladder cancer	-1.71	2.83e-2	40/41 (97.56%)	BRAF;EGFR;TP53;...
Drug metabolism	-1.72	2.47e-2	78/151 (51.66%)	CYP3A5;ADH1B;NME4;...
Porphyrin and chlorophyll metabolism	-1.72	2.45e-2	23/43 (53.49%)	ALAD;UGT2B28;ALAS2;...
Fructose and mannose metabolism	-1.73	2.36e-2	30/33 (90.91%)	PMM1;ALDOA;PFKFB3;...
Oxytocin signaling pathway	-1.73	2.34e-2	128/154 (83.12%)	NPR2;RYR2;RHOA;...
Ascorbate and aldarate metabolism	-1.82	5.97e-3	15/30 (50%)	UGT2B28;GUSB;KL;...
Renin-angiotensin system	-1.82	4.72e-3	20/23 (86.96%)	AGT;ENPEP;CTSG;...
Mitophagy	-1.82	5.00e-3	56/68 (82.35%)	TBC1D17;BCL2L1;ATG9A;...
Long-term potentiation	-1.82	5.32e-3	61/67 (91.04%)	PRKACB;PRKCB;RPS6KA3;...
Renin secretion	-1.85	2.83e-3	61/69 (88.41%)	AGT;PDE3B;GUCY1A1;...
Steroid hormone biosynthesis	-1.86	3.04e-3	43/61 (70.49%)	UGT2B15;CYP1A1;CYP3A4;...
Glycolysis / Gluconeogenesis	-1.86	2.18e-3	56/67 (83.58%)	LDHB;BPGM;PFKL;...
Retinol metabolism	-1.87	2.36e-3	41/68 (60.29%)	CYP3A5;ADH1B;DHRS3;...
Carbohydrate digestion and absorption	-1.87	2.58e-3	37/47 (78.72%)	PIK3CA;PRKCB;SLC2A2;...
Bacterial invasion of epithelial cells	-1.90	1.42e-3	59/77 (76.62%)	ITGB1;RAC1;CDC42;...
Gastric acid secretion	-1.91	1.57e-3	63/76 (82.89%)	PRKACB;PRKCB;MYLK;...
Endocrine and other factor-regulated calcium reabsorpti...	-1.97	0.00e+0	49/53 (92.45%)	ATP1B3;DNM1;KL;...
Pentose phosphate pathway	-2.04	0.00e+0	25/30 (83.33%)	PFKL;DERA;GPI;...
Pentose and glucuronate interconversions	-2.05	0.00e+0	17/34 (50%)	UGT2B28;GUSB;KL;...
Histidine metabolism	-2.09	0.00e+0	16/22 (72.73%)	MAOB;ALDH3A2;HNMT;...
Metabolism of xenobiotics by cytochrome P450	-2.10	0.00e+0	49/77 (63.64%)	CYP3A5;ADH1B;UGT2B28;...
Proximal tubule bicarbonate reclamation	-2.11	0.00e+0	21/23 (91.3%)	PCK2;ATP1B3;AQP1;...
Pancreatic secretion	-2.18	0.00e+0	87/102 (85.29%)	RAC1;ATP1B3;CCK;...
Bile secretion	-2.22	0.00e+0	68/90 (75.56%)	AQP8;ADCY1;UGT2B28;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H	Hide ▲
SK-N-SH	CVCL_0531	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12.5uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.03uM - 10uM	24H	Show ▼

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼