Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUF0BJ)

Drug Name
CYTISINE Drug Info
Synonyms
CYTISINE; 485-35-8; Sophorine; Baptitoxine; (-)-Cytisine; Laburnin; Baptitoxin; Tabex; Ulexin; Cytiton; Ulexine; Tsitizin; Cytitone; Cystisine; Cytizin; Citizin; Tabax; (1R,5S)-3,4,5,6-Tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one; Baphitoxine; UNII-53S5U404NU; Cytisine (-); HSDB 3560; EINECS 207-616-0; NSC 407282; BRN 0083882; Cytisin; (1r,5s)-1,2,3,4,5,6-Hexahydro-8h-1,5-Methanopyrido[1,2-A][1,5]diazocin-8-One; CHEBI:4055; CHEMBL497939; 53S5U404NU; Cytisine, 98%
Cross-matching ID
PubChem CID
10235
ChEBI ID
CHEMBL497939
CAS Number
CAS 485-35-8
TTD Drug ID
D08XPW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.80 3.17e-2 110/124 (88.71%) CDC20;SMC1A;E2F2;...
Pyrimidine metabolism 1.74 4.22e-2 40/56 (71.43%) TYMS;CDA;NME3;...
Regulation of lipolysis in adipocytes 1.74 3.76e-2 52/55 (94.55%) CGA;FABP4;PLAAT3;...
Spliceosome 1.73 3.96e-2 101/150 (67.33%) PUF60;PRPF8;SF3A2;...
Thermogenesis 1.70 4.75e-2 173/232 (74.57%) PPARG;CYC1;CREB1;...
Amino sugar and nucleotide sugar metabolism -1.65 4.88e-2 38/48 (79.17%) PGM3;NANS;HK3;...
Neutrophil extracellular trap formation -1.67 4.12e-2 101/189 (53.44%) RAC2;SELP;VDAC2;...
Glycosaminoglycan degradation -1.68 4.00e-2 19/19 (100%) GALNS;ARSB;HGSNAT;...
Lipid and atherosclerosis -1.68 4.19e-2 190/215 (88.37%) PTK2;JAK2;LDLR;...
Salmonella infection -1.71 3.14e-2 198/249 (79.52%) AKT3;BIRC3;DYNLRB1;...
Mineral absorption -1.71 3.19e-2 48/60 (80%) HEPH;MT1X;MT1E;...
NOD-like receptor signaling pathway -1.73 2.97e-2 145/181 (80.11%) RNASEL;DEFA5;TNFAIP3;...
Nicotine addiction -1.75 2.27e-2 32/40 (80%) GABRA1;GABRB3;GRIA3;...
Synaptic vesicle cycle -1.77 1.78e-2 63/78 (80.77%) ATP6V1C1;ATP6V1A;ATP6V0E2;...
Tyrosine metabolism -1.78 1.45e-2 30/36 (83.33%) TYR;ADH6;TPO;...
Fluid shear stress and atherosclerosis -1.80 1.04e-2 123/139 (88.49%) SELE;SDC2;SUMO1;...
NF-kappa B signaling pathway -1.87 8.48e-3 90/104 (86.54%) TRAF1;RIPK1;BLNK;...
IL-17 signaling pathway -1.90 7.91e-3 84/94 (89.36%) FOS;HSP90AB1;TRAF4;...
Rheumatoid arthritis -1.90 9.49e-3 78/93 (83.87%) ATP6V1A;ATP6V0E2;HLA-DOB;...
Other glycan degradation -1.98 0.00e+0 13/18 (72.22%) MAN2B2;ENGASE;HEXA;...
Epithelial cell signaling in Helicobacter pylori infect... -1.99 0.00e+0 62/70 (88.57%) F11R;HBEGF;ATP6V1C1;...
Lysosome -2.01 0.00e+0 115/128 (89.84%) CTSF;AP4S1;AP1G2;...
Collecting duct acid secretion -2.10 0.00e+0 22/27 (81.48%) ATP6V1C1;SLC4A1;ATP6V1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H