Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUF8JZ)

Drug Name
veratridine Drug Info
Synonyms veratrine; 3-veratroylveracevine
Cross-matching ID
PubChem CID
6280
ChEBI ID
CHEMBL439496
CAS Number
CAS 71-62-5
TTD Drug ID
D0S4MN
VARIDT Drug ID
DR01020

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ether lipid metabolism -1.77 4.24e-2 32/49 (65.31%) PLA2G12A;PLA2G1B;LPCAT4;...
Folate biosynthesis -1.77 4.86e-2 23/26 (88.46%) ALPL;MOCS2;PCBD1;...
D-Glutamine and D-glutamate metabolism -1.82 1.93e-2 5/5 (100%) DGLUCY;GLS;GLUD1;...
Mitophagy -1.95 7.37e-3 56/68 (82.35%) ATG9A;TFEB;ATG5;...
Mineral absorption -1.96 1.11e-2 48/60 (80%) MT1X;ATP7B;FXYD2;...
Ferroptosis -2.11 0.00e+0 36/41 (87.8%) PCBP2;NCOA4;ACSL4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 8uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H