Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUGHWR)

• Drug Name: WP-1066 Drug Info
• Synonyms: WP1066; 857064-38-1; (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide; WP 1066; UNII-63V8AIE65T; 63V8AIE65T; WP-1066; AK-99218; C17H14BrN3O; (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide; MLS006010178; SCHEMBL1315826; QCR-16; SCHEMBL1315831; GTPL7972; CHEMBL1923234; EX-A760; AOB1497; DTXSID50235007; MolPort-044-723-708; MolPort-023-219-149; ZINC13983221; AKOS016007983; WP1066/WP-1066; CS-2736; DB12679; 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-, (2E)-; HY-15312
• Cross-matching ID:
  PubChem CID: 11210478
  ChEBI ID: CHEMBL1923234
  CAS Number: CAS 857064-38-1
  TTD Drug ID: D0IV4C

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Taurine and hypotaurine metabolism	-1.66	4.48e-2	8/11 (72.73%)	CSAD;ADO
Glyoxylate and dicarboxylate metabolism	-1.69	3.78e-2	23/30 (76.67%)	MDH1;SHMT2;MMUT;...
Fatty acid elongation	-1.70	3.18e-2	19/27 (70.37%)	HSD17B12;MECR;HADH;...
Arginine and proline metabolism	-1.71	3.31e-2	39/50 (78%)	ALDH9A1;ARG1;CKB;...
Other glycan degradation	-1.76	2.02e-2	13/18 (72.22%)	MAN2C1;MAN2B1;GLB1;...
Pentose phosphate pathway	-1.77	1.74e-2	25/30 (83.33%)	H6PD;PGD;ALDOA;...
Type I diabetes mellitus	-1.83	1.12e-2	38/43 (88.37%)	HLA-DRA;HLA-A;FAS;...
Biosynthesis of unsaturated fatty acids	-1.86	9.61e-3	21/27 (77.78%)	HSD17B12;HSD17B4;HACD2;...
Oxidative phosphorylation	-1.86	1.04e-2	93/133 (69.92%)	ATP5MC1;COX7A2;ATP5F1B;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	-1.86	1.04e-2	20/26 (76.92%)	PIGN;PIGO;PIGG;...
Tryptophan metabolism	-1.88	1.04e-2	35/42 (83.33%)	DLST;DDC;ALDH9A1;...
Peroxisome	-1.90	1.04e-2	72/82 (87.8%)	ACOX1;PMVK;IDH2;...
Allograft rejection	-1.91	1.04e-2	32/38 (84.21%)	HLA-DRA;HLA-A;FAS;...
Citrate cycle (TCA cycle)	-1.96	4.46e-3	30/30 (100%)	ACO2;SDHB;DLST;...
Pyruvate metabolism	-1.99	5.21e-3	41/47 (87.23%)	ADH7;ACYP2;ME1;...
Fatty acid biosynthesis	-2.04	0.00e+0	16/18 (88.89%)	HSD17B8;MECR;ACSL3;...
Propanoate metabolism	-2.04	0.00e+0	30/34 (88.24%)	MMUT;DBT;BCKDHA;...
Fatty acid degradation	-2.19	0.00e+0	40/43 (93.02%)	ADH7;ACOX1;ALDH9A1;...
Butanoate metabolism	-2.31	0.00e+0	23/28 (82.14%)	AACS;ACAT1;ACAT2;...
Valine, leucine and isoleucine degradation	-2.40	0.00e+0	42/48 (87.5%)	ALDH9A1;MCCC2;MMUT;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 3.33uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲