Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUGQIV)

Drug Name
2-chloro-5-nitro-N-phenylbenzamide Drug Info
Synonyms
2-Chloro-5-nitro-N-phenylbenzamide; GW9662; 22978-25-2; GW 9662; 2-Chloro-5-nitrobenzanilide; GW-9662; MLS001056751; CHEBI:79993; 2-Chloro-5-nitro-N-phenyl-benzamide; 2-Chloro-5-nitro-N-4-phenylbenzamide; benzamide, 2-chloro-5-nitro-N-phenyl-; SMR000326735; (2-chloro-5-nitrophenyl)-N-benzamide; SR-01000075999; Tocris-1508; Spectrum5_001989; Lopac-M-6191; AC1LD8S0; DSSTox_RID_79570; DSSTox_CID_20723; DSSTox_GSID_40723; Lopac0_000798; KBioGR_000361; KBioSS_000361; BSPBio_001021; SCHEMBL420231; CHEMBL375270; GTPL3442; cid_644213
Cross-matching ID
PubChem CID
644213
ChEBI ID
CHEMBL79993
CAS Number
CAS 22978-25-2
TTD Drug ID
D00ACX
INTEDE Drug ID
DR2165

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.63 0.00e+0 34/36 (94.44%) MCM5;MCM3;RFC4;...
Cell cycle 2.23 0.00e+0 110/124 (88.71%) CDC20;CCNA2;PLK1;...
Homologous recombination 2.01 9.25e-3 35/41 (85.37%) RAD51;POLD1;BRCA1;...
Progesterone-mediated oocyte maturation 2.01 6.94e-3 75/100 (75%) HSP90AA1;CCNA2;PLK1;...
Oocyte meiosis 1.96 8.32e-3 90/129 (69.77%) CDC20;PLK1;CCNB1;...
Pyrimidine metabolism 1.94 6.94e-3 40/56 (71.43%) RRM2;TYMS;RRM1;...
Mismatch repair 1.92 9.91e-3 22/23 (95.65%) RFC4;POLD1;EXO1;...
VEGF signaling pathway 1.79 3.29e-2 50/59 (84.75%) PRKCA;PIK3CA;SPHK1;...
Fc epsilon RI signaling pathway 1.78 3.24e-2 57/68 (83.82%) PRKCA;PIK3CA;PIK3CD;...
Base excision repair 1.74 3.88e-2 29/33 (87.88%) HMGB1;FEN1;POLD1;...
RNA transport 1.72 4.29e-2 128/186 (68.82%) EIF1AY;TACC3;NUP50;...
Bacterial invasion of epithelial cells 1.70 4.62e-2 59/77 (76.62%) PIK3CA;MET;PIK3CD;...
Fanconi anemia pathway 1.70 4.37e-2 36/54 (66.67%) FANCI;RAD51;CENPX;...
Folate biosynthesis 1.70 4.16e-2 23/26 (88.46%) GGH;DHFR;AKR1B10;...
Circadian rhythm -1.73 4.59e-2 26/31 (83.87%) SKP1;CRY1;PER2;...
Steroid biosynthesis -1.81 1.74e-2 19/20 (95%) DHCR7;FDFT1;TM7SF2;...
Complement and coagulation cascades -1.83 1.62e-2 76/85 (89.41%) C7;TFPI;THBD;...
Other glycan degradation -1.83 2.44e-2 13/18 (72.22%) HEXA;MANBA;MAN2B2;...
PPAR signaling pathway -1.89 6.96e-3 66/74 (89.19%) PCK2;ACSBG1;CD36;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H