Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUIBV8)

Drug Name
Azimilide Drug Info
Synonyms Azimilide [INN:BAN]; 1-({[5-(4-chlorophenyl)furan-2-yl]methylidene}amino)-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione
Cross-matching ID
PubChem CID
9571004
ChEBI ID
CHEMBL123558
CAS Number
CAS 149908-53-2
TTD Drug ID
D0J6II
INTEDE Drug ID
DR0167

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Biosynthesis of unsaturated fatty acids 2.20 0.00e+0 21/27 (77.78%) SCD;FADS1;FADS2;...
Peroxisome 2.10 0.00e+0 72/82 (87.8%) PEX6;HSD17B4;IDH1;...
Steroid biosynthesis 1.92 1.10e-2 19/20 (95%) MSMO1;DHCR24;SC5D;...
Terpenoid backbone biosynthesis 1.91 8.27e-3 18/22 (81.82%) ACAT2;HMGCS1;FDPS;...
Histidine metabolism 1.87 9.93e-3 16/22 (72.73%) MAOA;AOC1;HNMT;...
Arginine biosynthesis 1.84 1.10e-2 17/22 (77.27%) ASS1;GLUL;GOT2;...
Graft-versus-host disease -1.73 4.89e-2 32/42 (76.19%) PRF1;GZMB;HLA-E;...
Toxoplasmosis -1.77 2.71e-2 103/112 (91.96%) CASP3;IFNG;MAPK1;...
Dilated cardiomyopathy -1.78 3.16e-2 86/96 (89.58%) SGCD;SGCA;MYH7;...
Intestinal immune network for IgA production -1.78 3.79e-2 38/48 (79.17%) ITGA4;IL15;ICOS;...
Arrhythmogenic right ventricular cardiomyopathy -1.79 4.74e-2 70/77 (90.91%) ITGB5;DSP;TCF7;...
Autoimmune thyroid disease -1.96 1.18e-2 46/53 (86.79%) PRF1;GZMB;HLA-E;...
Viral myocarditis -2.00 0.00e+0 53/60 (88.33%) HLA-A;CASP3;ABL1;...
Allograft rejection -2.04 0.00e+0 32/38 (84.21%) PRF1;GZMB;HLA-E;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 3.33uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H