Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMULZ4W)

Drug Name
CHR-2797 Drug Info
Synonyms Tosedostat; Tosedostat, CHR2797, CHR-2797
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
15547703
ChEBI ID
CHEMBL2103847
CAS Number
CAS 238750-77-1
TTD Drug ID
D0F2JS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.41 0.00e+0 44/46 (95.65%) PSMD11;PSMD4;PSMB2;...
Cysteine and methionine metabolism 2.06 0.00e+0 43/50 (86%) PSAT1;PHGDH;BCAT1;...
Viral protein interaction with cytokine and cytokine re... 2.05 0.00e+0 84/100 (84%) CXCL5;CXCL13;CXCL14;...
TNF signaling pathway 1.93 4.20e-3 103/112 (91.96%) CXCL5;VCAM1;NFKBIA;...
Selenocompound metabolism 1.91 3.36e-3 11/17 (64.71%) CTH;TXNRD1;PAPSS1;...
Epithelial cell signaling in Helicobacter pylori infect... 1.83 9.80e-3 62/70 (88.57%) NFKBIA;CXCL3;ATP6V1C1;...
IL-17 signaling pathway 1.83 8.40e-3 84/94 (89.36%) CXCL5;NFKBIA;MMP3;...
Cytosolic DNA-sensing pathway 1.80 8.40e-3 52/63 (82.54%) NFKBIA;ADAR;POLR3E;...
Alanine, aspartate and glutamate metabolism 1.80 7.47e-3 27/37 (72.97%) ASNS;ASS1;NIT2;...
NOD-like receptor signaling pathway 1.77 1.34e-2 145/181 (80.11%) NFKBIA;OAS2;OAS1;...
Glycine, serine and threonine metabolism 1.75 1.37e-2 31/40 (77.5%) PSAT1;PHGDH;SHMT2;...
Ferroptosis 1.73 1.89e-2 36/41 (87.8%) HMOX1;SLC7A11;SLC3A2;...
NF-kappa B signaling pathway 1.68 3.68e-2 90/104 (86.54%) RELB;VCAM1;NFKBIA;...
Rheumatoid arthritis 1.68 3.54e-2 78/93 (83.87%) CXCL5;MMP3;CXCL3;...
Folate biosynthesis 1.65 4.42e-2 23/26 (88.46%) AKR1C3;AKR1B10;AKR1B1;...
Riboflavin metabolism 1.64 4.41e-2 7/8 (87.5%) FLAD1;BLVRB;ACP5;...
RIG-I-like receptor signaling pathway 1.62 4.85e-2 64/70 (91.43%) NFKBIA;CXCL10;DDX58;...
Carbohydrate digestion and absorption -1.68 4.59e-2 37/47 (78.72%) PLCB1;HK3;SLC2A5;...
Cardiac muscle contraction -1.69 4.90e-2 64/87 (73.56%) ACTC1;MYH7;MYL3;...
Terpenoid backbone biosynthesis -1.70 4.93e-2 18/22 (81.82%) FDPS;PDSS1;HMGCS1;...
p53 signaling pathway -1.73 4.59e-2 63/73 (86.3%) CASP3;ATM;IGF1;...
VEGF signaling pathway -1.78 2.87e-2 50/59 (84.75%) PIK3R1;BAD;PXN;...
Retinol metabolism -1.82 2.07e-2 41/68 (60.29%) DGAT1;ADH1A;RDH5;...
Systemic lupus erythematosus -1.85 1.72e-2 45/135 (33.33%) ACTN4;HLA-DPB1;C8B;...
Steroid biosynthesis -1.91 1.53e-2 19/20 (95%) SQLE;LSS;CYP51A1;...
Aldosterone-regulated sodium reabsorption -2.00 1.72e-2 34/37 (91.89%) NR3C2;IRS1;NEDD4L;...
Asthma -2.05 2.29e-2 25/31 (80.65%) HLA-DPB1;HLA-DPA1;TNF;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 80uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 80uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 80uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 80uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 80uM 6H
MDST8 CVCL_1400 Homo sapiens 80uM 6H
NCI-H508 CVCL_1561 Homo sapiens 80uM 6H
SNU-1040 CVCL_5001 Homo sapiens 80uM 6H
SNU-C4 CVCL_5008 Homo sapiens 80uM 6H
SNU-C5 CVCL_5009 Homo sapiens 80uM 6H
SW480 CVCL_0546 Homo sapiens 80uM 6H
SW620 CVCL_0547 Homo sapiens 80uM 6H
SW948 CVCL_0550 Homo sapiens 80uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 80uM 6H
HT115 CVCL_1294 Homo sapiens 80uM 6H
RKO CVCL_0504 Homo sapiens 80uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 80uM 6H
SNG-M CVCL_1707 Homo sapiens 80uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 80uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 80uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 80uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 80uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 80uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 80uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 80uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 80uM 6H
T3M-10 CVCL_1729 Homo sapiens 80uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 80uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 80uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 80uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 80uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 80uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 80uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 80uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 80uM 6H
OV7 CVCL_1623 Homo sapiens 80uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 80uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 80uM 6H
RMUG-S CVCL_1666 Homo sapiens 80uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 80uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 80uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 80uM 6H
PL-21 CVCL_2161 Homo sapiens 80uM 6H
SKM-1 CVCL_0010 Homo sapiens 80uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 80uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 80uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 80uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 80uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 80uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 80uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 80uM 6H