Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUN54G)

Drug Name
AMINOHIPPURIC ACID Drug Info
Synonyms
4-Aminohippuric acid; aminohippuric acid; 61-78-9; P-AMINOHIPPURIC ACID; Paha; Glycine, N-(4-aminobenzoyl)-; N-(4-Aminobenzoyl)glycine; para-Aminohippuric acid; Nefrotest; 2-(4-aminobenzamido)acetic acid; N-(p-Aminobenzoyl)glycine; p-Aminohippurate; Aminohippurate; PAH (amino acid); 4-Amino hippuric acid; N-(para-aminobenzoyl)glycine; Hippuric acid, p-amino-; N-(p-Aminobenzoyl)aminoacetic acid; para-Aminohippurate; paraaminohippuric acid; PAH; UNII-Y79XT83BJ9; NSC 13064; HSDB 2139; 4-Aminobenzoyl Glycine; EINECS 200-518-9
Cross-matching ID
PubChem CID
2148
ChEBI ID
CHEMBL463
CAS Number
CAS 61-78-9
TTD Drug ID
D04DLM
VARIDT Drug ID
DR00067

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.33 0.00e+0 113/158 (71.52%) RPL36;MRPS16;RPS27L;...
Fatty acid biosynthesis 1.97 6.87e-3 16/18 (88.89%) ACSL4;ACSL3;FASN;...
Thermogenesis 1.85 1.15e-2 173/232 (74.57%) PLIN1;MGLL;GNAS;...
T cell receptor signaling pathway -1.72 3.53e-2 93/104 (89.42%) GRAP2;IL4;GRB2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.74 3.13e-2 79/89 (88.76%) BATF;EGF;CD3D;...
Phototransduction -1.75 3.31e-2 21/29 (72.41%) RGS9;GNB1;CALML3;...
Autoimmune thyroid disease -1.78 2.50e-2 46/53 (86.79%) CTLA4;TSHR;IL4;...
Th17 cell differentiation -1.80 1.82e-2 95/107 (88.79%) HLA-DOA;HSP90AA1;MAPK1;...
Antigen processing and presentation -1.81 1.70e-2 60/78 (76.92%) HLA-DPA1;HLA-DOA;HSP90AA1;...
Allograft rejection -1.83 1.10e-2 32/38 (84.21%) HLA-DPA1;HLA-DOA;HLA-C;...
Graft-versus-host disease -1.90 5.29e-3 32/42 (76.19%) HLA-DPA1;HLA-DOA;HLA-C;...
Asthma -1.94 3.31e-3 25/31 (80.65%) FCER1G;IL3;IL4;...
Primary immunodeficiency -1.99 4.41e-3 33/38 (86.84%) CD3D;ZAP70;CD19;...
Th1 and Th2 cell differentiation -2.14 0.00e+0 80/92 (86.96%) NOTCH3;HLA-DPA1;HLA-DOA;...
Hematopoietic cell lineage -2.18 0.00e+0 90/99 (90.91%) IL7R;CD7;CD37;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H