Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUNJZB)

• Drug Name: UCN-01 Drug Info
• Synonyms: UCN; UCN01; Ucn 01; KRX-0601; KW-2401; UCN-02; (5s,6r,7r,9r,16r)-16-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one; 7-Hydroxystaurosporine; 7-hydroxystaurosporine (UCN-01)
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 72271
  ChEBI ID: CHEMBL1236539
  CAS Number: CAS 112953-11-4
  TTD Drug ID: D0Z9VY
  VARIDT Drug ID: DR01437

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.51	0.00e+0	19/20 (95%)	LSS;SQLE;DHCR24;...
Terpenoid backbone biosynthesis	2.24	0.00e+0	18/22 (81.82%)	ACAT2;HMGCS1;FDPS;...
Biosynthesis of unsaturated fatty acids	1.84	4.33e-2	21/27 (77.78%)	SCD;FADS1;HACD1;...
Graft-versus-host disease	-1.77	4.97e-2	32/42 (76.19%)	KLRD1;CD86;FASLG;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	-1.88	7.11e-3	20/26 (76.92%)	PIGN;PIGA;PIGG;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow

Chronic myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HAP1	CVCL_Y019	Homo sapiens	0.66uM - 3.33uM	24H	Hide ▲
HAP1 CDK4 (-) 1	CVCL_SI36	Homo sapiens	0.66uM - 3.33uM	24H	Hide ▲
HAP1 HDAC5 (-) 1	CVCL_SR11	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 ITGA4 (-) 1	CVCL_ST27	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 MAPK8 (-) 1	CVCL_SW99	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 PIK3CA (-) 1	CVCL_TD60	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 PRKACA (-) 1	CVCL_TG70	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 PRKCQ (-)	CVCL_TG92	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 RELA (-) 1	CVCL_TI75	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 SRC (-) 1	CVCL_TQ36	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 TP53 (-) 1	CVCL_RJ70	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼

Breast

Fibrocystic breast disease

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A (Parent)	CVCL_0598	Homo sapiens	1.11uM - 10uM	3H, 6H, 12H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼